中山大学学报（医学科学版）2025，Vol.46Issue(2)：197-209,13.
慢性疼痛与负性情绪的神经交互机制及综合干预策略研究进展
The Research Progress on the Neural Interaction Mechanisms and Integrated Intervention Strategies of Chronic Pain and Negative Emotions
摘要
Abstract
Chronic pain patients often experience varying degrees of negative emotions,such as anxiety and depression,and the persistent presence of these negative emotions may further exacerbate chronic pain.When treating chronic pain,improving either aspect of pain or negative emotions,the other symptom will also be alleviated.The brain regions involved in chronic pain and negative emotions partially overlap and share similar neurophysiological mechanisms,which may be one of the important reasons for their interaction.Multiple brain regions play synergistic roles in pain-related emotional,cognitive,and motivational processing,especially brain regions such as the amygdala,prefrontal cortex,nucleus accumbens,and ventral tegmental area in the cerebral cortex-limbic system,which are critical for the recognition and processing of emotional information.Currently,the clinical treatment of chronic pain remains challenging,especially the limitations of existing pharmacologic treatments.Therefore,benign regulation of negative emotions occupies an important place in the treatment of chronic pain as one of the important intervention targets.In this paper,on the basis of summarizing the neural mechanisms that generate negative emotions in chronic pain,a variety of current therapeutic options for chronic pain related negative emotions are summarize and organized,including pharmacotherapy,non-invasive neuromodulation,psychotherapy,and acupuncture.The combined application of these options not only helps to alleviate patients' negative emotions,but also provides more precise therapeutic targets and more effective strategies for future research.The aim of this article is to deepen beginners' understanding of the background of chronic pain pathophysiology and to provide a reference for clinical practice and research.关键词
慢性疼痛/负性情绪/药物治疗/无创神经调控/心理疗法/中医针灸Key words
chronic pain/negative emotions/pharmacotherapy/non-invasive neuromodulation/psychotherapy/acupuncture分类
医药卫生引用本文复制引用
王笑珂,舒晴..慢性疼痛与负性情绪的神经交互机制及综合干预策略研究进展[J].中山大学学报（医学科学版）,2025,46(2):197-209,13.基金项目
湖北省自然科学基金(2022CFB192) （2022CFB192）
武汉大学中南医院创新培育基金(CXPY2022041) （CXPY2022041）
