中山大学学报（医学科学版）2025，Vol.46Issue(2)：230-237,8.
非编码RNA调控铜死亡相关基因在消化道肿瘤中的研究进展
Noncoding RNAs Regulate Cuproptosis-related Genes in Digestive Tract Tumors:Research Progress
摘要
Abstract
Copper is a trace element in the human body and is closely related to various signaling pathways and tumor-related biological behaviors.However,when its concentration exceeds the threshold maintained by homeostatic mechanisms,it becomes toxic and triggers cell death.Cuproptosis is a novel form of cell death,distinct from all other known cell death pathways.It occurs through the direct binding of copper to the lipoic acid components of the tricarboxylic acid cycle,leading to the aggregation of lipoic-acylated proteins and the loss of iron-sulfur cluster proteins.This triggers protein toxicity stress,ultimately resulting in cell death.Cuproptosis plays a role in the occurrence,development,and prognosis of digestive tract tumors.Noncoding RNAs(ncRNAs)such as long non-coding RNA(lncRNA),micro RNA(miRNA)and circular RNA(circRNA)directly or indirectly regulate the expression of cuproptosis-related genes(FDX1,LIPT1,LIAS,DLD,DLAT,PDHA1,PDHB,MTF1,GLS and CDKN2A)in digestive tract tumors based on ceRNA mechanism,thereby inducing copper ion accumulation,driving oxidative stress response,protein fatty acylation and ubiquitin-proteasome system,inhibiting the occurrence and development of digestive tract tumor cells.NcRNAs'implication in the genesis of tumor cells via regulating cuproptosis-related genes provides a new insight into precision-targeted therapy for tumors.This article introduces cuproptosis,outlines the various regulatory mechanisms of cuproptosis,and provides an overview of ncRNAs and their roles.It reviews recent research on ncRNAs involved in regulating cuproptosis in digestive tract tumors such as esophageal squamous cell carcinoma,gastric cancer,hepatocellular carcinoma,colorectal carcinoma,pancreatic cancer,along with their molecular mechanisms.The article also presents clinical perspectives,aiming to provide a theoretical basis for the diagnosis and treatment of digestive tract tumors.关键词
铜死亡/非编码RNA/消化道肿瘤/信号轴/综述Key words
cuproptosis/non-coding RNAs/digestive tract tumors/signal axis/review分类
医药卫生引用本文复制引用
杜予心,王小平..非编码RNA调控铜死亡相关基因在消化道肿瘤中的研究进展[J].中山大学学报（医学科学版）,2025,46(2):230-237,8.基金项目
国家自然科学基金(82460515) （82460515）
中央引导地方科技发展资金项目(LSKJ202447) （LSKJ202447）
咸阳市科技计划重点研发项目(L2024-ZDYF-SF-0025) （L2024-ZDYF-SF-0025）
