中山大学学报（医学科学版）2025，Vol.46Issue(2)：245-256,12.
巨噬细胞对口腔白斑病发展的影响
Effects of Macrophages on the Development of Oral Leukoplakia
摘要
Abstract
Oral leukoplakia is a potentially malignant mucosal disease with a high incidence rate.Macrophages play a significant regulatory role in the malignant transformation of oral leukoplakia,yet there is a lack of research on the molecular mechanisms underlying this process.Recent studies have found that M2 polarization of macrophages has a significant impact on the malignant transformation of oral leukoplakia,and this process is regulated by a complex network involving immune cells,microorganisms,cytokines,and the extracellular matrix,etc.Therefore,this article reviews the biological functions,subtypes,and regulatory factors of macrophage polarization in oral leukoplakia.Building on the preliminary research foundation of our group on the relationship between oral intracellular colonizing bacteria and mucosal malignant tumors,it is proposed that oral intracellular colonizing bacteria,such as Porphyromonas gingivalis,may promote the malignant transformation of leukoplakia by inducing a macrophage M2 polarization that leads to an immunosuppressive microenvironment.This perspective explores potential intervention strategies from the angle of macrophage polarization,providing new research directions for the prevention and treatment of oral leukoplakia and oral cancer.关键词
口腔黏膜病学/巨噬细胞/口腔白斑病/免疫调控/恶性转化/极化Key words
oral medicine/macrophages/oral leukoplakia/immunoregulation/malignant transformation/polarization分类
医药卫生引用本文复制引用
贾益群,郑雨燕..巨噬细胞对口腔白斑病发展的影响[J].中山大学学报（医学科学版）,2025,46(2):245-256,12.基金项目
深圳市基础研究专项(自然科学基金)(JCYJ20220530152204011) （自然科学基金）
深圳市医学研究专项(A2303027) （A2303027）
深圳市医疗卫生三名工程(SZSM202311009) （SZSM202311009）
