中山大学学报（医学科学版）2025，Vol.46Issue(2)：328-334,7.
改良危重症营养风险评分与急诊重症监护室脓毒症患者住院病死率的相关性分析
Correlation Analysis of Modified Nutritional Risk in Critically Ill Score with In-hospital Fatality in Sepsis Patients in the Emergency Intensive Care Unit
摘要
Abstract
[Objective]To clarify the application value of nutritional scoring in patients with sepsis and explore the impact of the modified Nutritional Risk in Critically Ill(mNUTRIC)score on the in-hospital fatality of sepsis patients in the emergency intensive care unit(EICU).[Methods]A retrospective analysis was conducted on the clinical data and laboratory examination results of 436 sepsis patients treated in the EICU of Sun Yat-sen Memorial Hospital of Sun Yat-sen University from January 2021 to May 2024.The patients were divided into survival group(298 cases)and death group(138 cases)according to whether they died or not during hospital treatment,and then compared the two groups'data.Logistic multi-factor regression analysis was used to analyze the risk factors for in-hospital death and the ROC curve to evaluate the predictive value of each risk factor for the prognosis of sepsis patients.[Results]The death group exhibited higher Acute Physiology and Chronic Health EvaluationⅡ(APACHE Ⅱ)score,Nutritional Risk Screening 2002(NRS 2002)score,mNUTRIC score,Sequential Organ Failure Assessment(SOFA)score,Padua Prediction Score for Venous Thromboembolism,the proportions of chronic kidney failure and pneumonia patients,C-reactive protein(CRP)level,lactate concentration and neutrophil count,but lower prognostic nutritional index,cholinesterase level,cholinesterase-albumin ratio and lymphocyte count than the survival group,with statistical significance(all P<0.05).Logistic regression analysis revealed that the mNUTRIC score[OR=1.254,95%CI(1.109,1.417)],CRP[OR=1.004,95%CI(1,1.007)],and pneumonia[OR=1.82,95%CI(1.017,3.257)]were independent risk factors for in-hospital death in sepsis patients.ROC curve analysis showed that the area under the curve(AUC)of the mNUTRIC score for predicting in-hospital death in sepsis patients was 0.683[95%CI(0.623,0.742)],with a sensitivity of 83%and a specificity of 49.3%.The AUC for CRP and pneumonia were 0.602[95%CI(0.533,0.671)],and 0.582[95%CI(0.516,0.647)].[Conclusion]The mNUTRIC score is an independent predictive indicator for in-hospital death in sepsis patients in the EICU.关键词
mNUTRIC评分/脓毒症/危险因素/营养/预后Key words
modified Nutritional Risk in Critically Ill(mNUTRIC)score/sepsis/risk factor/nutrition/prognosis分类
医药卫生引用本文复制引用
李水仙,唐俊鹏,杨正飞,刘婉弟,王鹏飞..改良危重症营养风险评分与急诊重症监护室脓毒症患者住院病死率的相关性分析[J].中山大学学报（医学科学版）,2025,46(2):328-334,7.基金项目
国家自然科学基金(82372207) （82372207）
