电化学（中英文）2025，Vol.31Issue(3)：35-46,12.DOI:10.61558/2993-074X.3503
基于Au@MoS2的多巴胺电化学传感研究
Study on Dopamine Electrochemical Sensing Based on Au@MoS2
摘要
Abstract
Dopamine(DA)is a vital neurotransmitter,and accurate detection of its concentration is critical for both clinical diagnos-tics and neuroscience research.Due to its electrochemical activity,DA is commonly detected using electrochemical methods,which are favored for their simplicity,fast response time,and suitability for in vivo analysis.In this work,a highly sensitive DA electrochemical sensor was developed using an Au@MoS2 composite,created by modifying molybdenum disulfide(MoS2)nanosheets with gold nanoparticles through HAuCl4 reduction,and it was aimed at enhancing DA adsorption and improving detection performance.Scanning Electron Microscopy(SEM),transmission electron microscopy(TEM),Energy Dispersive Spectroscopy(EDS),X-ray photoelectron spectroscopy(XPS)and X-ray Diffraction(XRD)confirmed the suc-cessful synthesis of Au@MoS2 and the uniform distribution of gold nanoparticles across the MoS2 nanosheets.Then,the electrochemical characterization demonstrated that the Au@MoS2/GCE exhibited distinct oxidation peaks in a 10 μmol·L-1 DA solution,with significantly enhanced electrochemical activity compared to both unmodified GCE and pristine MoS2.Furthermore,differential pulse voltammetry(DPV)further revealed a strong linear relationship between DA concentration and the current response in the range of 800 nmol·L-1 to 10 μmol·L-1,with a low detection limit(LOD)of 78.9 nmol·L-1(S/N=3).Additionally,the sensor showed excellent selectivity against other interfering substances.Moreover,the laser-induced Au@MoS2(LIAu@MoS2),with its abundance of negatively charged surface defects,enabled the ultra-sensitive detection of the ultra-low concentrations of DA.In conclusion,the successfully fabricated Au@MoS2 based sensor offers advantages such as low cost,ease of operation,and scalability,making it a promising candidate for biosensing applications due to its enhanced DA detection capabilities.关键词
多巴胺/电化学传感/二硫化钼/金纳米颗粒Key words
Dopamine/Electrochemical sensor/Molybdenum disulfide/Gold nanoparticles引用本文复制引用
安宁,苏妮,李欣然,刘建宇,王其炎..基于Au@MoS2的多巴胺电化学传感研究[J].电化学（中英文）,2025,31(3):35-46,12.基金项目
This work was financially supported by the Young Talent Innovation Team Support Project from Zheng-zhou University(No.32213280),the scientific re-search program of innovation platform in State To-bacco Monopoly Administration and the State Key Program of National Natural Science Foundation of China(Grant No.32130083). （No.32213280）
