摘要
Abstract
Objective:To probe into the related factors of macrolide resistance in children with non severe Mycoplasma pneumoniae pneumonia(N-SMPP).Methods:Retrospective analysis of 85 children with N-SMPP hospitalized in Lu'an People's Hospital of Anhui from Apr.2023 to Aug.2024.All the children were treated with bronchoscopy and bronchoalveolar lavage and submitted for targeted next-generation sequencing(tNGS).A total of 35 cases of macrolide-resistant M.pneumoniae pneumonia(MPP)were extracted as the observation group,while the remaining 50 patients served as the control group.General clinical data of two groups were compared,and the factors affecting drug resistance were analyzed by multiple logistic regression.Results:There were no significant differences in gender,age,imaging findings,white blood cells,alanine aminotransferase level,aspartate aminotransferase level and length of stay between two groups(P＞0.05).There were statistically signifi cant difference in neutrophil count,C-reactive protein,erythrocyte sedimentation rate(ESR),lactate dehydrogenase(LDH)levels and non-responsiveness of macrolide between two groups(P＜0.05).Multivariate logistic regression analysis showed that ESR,elevated LDH and non-responsiveness of macrolide were risk factors for macrolide resistance(P＜0.05).Conclusion:According to ESR,elevated LDH level and non-responsiveness of macrolide,macrolide-resistant MPP can be identified,which is of great significance for guiding clinicians to judge the condition of children and formulate treatment regimens.关键词
儿童/肺炎支原体肺炎/耐药基因检测/大环内酯类/无反应性Key words
children/Mycoplasma pneumoniae pneumonia/drug resistance gene testing/macrolide/non-responsiveness分类
医药卫生
