儿科药学杂志2025，Vol.31Issue(4)：14-17,4.DOI:10.13407/j.cnki.jpp.1672-108X.2025.04.004
某儿童医院31 744例次丙戊酸治疗药物监测结果的回顾性分析
Retrospective Analysis on 31,744 Cases of Therapeutic Drug Monitoring of Valproate in a Children's Hospital
邓后亮 1谢萍 1莫小兰1
作者信息
- 1. 广州医科大学附属妇女儿童医疗中心,广州 510120
- 折叠
摘要
Abstract
Objective:To analyze the therapeutic drug monitoring(TDM)results of valproate in children with epilepsy,and provide reference for individualized medication therapy.Methods:The gender,age,and blood concentration data of all outpatient and inpatient children with epilepsy who underwent TDM of valproate in our hospital from 2012 to 2023 were collected and statistically analyzed.Results:A total of 9,209 pediatric epilepsy patients received TDM from 2012 to 2023 were monitored 31,744 times.The blood concentration of valproate was＜50 mg/L in 11,477 cases(36.2％),50 to 100 mg/L in 18,186 cases(57.3％),and＞100 mg/L in 2,081 cases(6.6％).There were statistically significant differences in the distribution of valproate concentration among patients of different age groups,genders,and visit types(P＜0.05).The valproate concentration in outpatients was higher than that in inpatients(P＜0.01).There were significantly differences in valproate concentration among different age groups(P＜0.01).There was no significantly difference in valproate concentration between male and female patients(P＞0.05).Multiple linear regression analysis showed that gender and age had a statistically significant impact on valproate concentration(P＜0.01).Conclusion:The blood concentration of valproate varies greatly among pediatric individuals.Individualized administration can be considered with patients'gender and age to increase the proportion of valproate concentration within the treatment reference range.关键词
丙戊酸/治疗药物监测/血药浓度/儿童/个体化用药Key words
valproate/therapeutic drug monitoring/blood concentration/children/individualized administration分类
药学引用本文复制引用
邓后亮,谢萍,莫小兰..某儿童医院31 744例次丙戊酸治疗药物监测结果的回顾性分析[J].儿科药学杂志,2025,31(4):14-17,4.
