摘要
Abstract
Objective:To retrospectively analyze the adverse drug reactions(ADR)reports of children under 18 years reported by medical institutions in Hezhou from Jan.2014 to Jun.2024,and to explore the occurrence,characteristics and main causes of ADR in children,so as to provide reference for monitoring and rational drug use of ADR in children.Methods:Retrospective analysis was used to statistically analyze the types of ADR reports,clinical manifestations,timing of occurrence,drug categories,administration routes,and age and gender distributions of affected children.Results:Among the 3,531 ADR reports collected,2,586 cases(73.23％)were general ADR,688 cases were new general ADR(19.48％),217 cases were severe ADR(6.15％)and 40 cases were new severe ADR(1.13％).The age of children with ADR mainly ranged from ≥ 28 d to 7 years.The main administration routes of ADR were intravenous infusion in 2,973 cases(84.20％),intravenous injection in 95 cases(2.69％),and intra-pump injection in 29 cases(0.82％),followed by oral administration in 258 cases(7.31％).The top 3 drug categories of ADR were respectively antibacterial drugs in 1,518 cases(42.99％),Chinese patent medicine in 845 cases(23.93％)and antiviral drugs in 346 cases(9.80％).The top 10 drugs with the highest ADR were respectively Shuanghuanglian injection(lyophilized),Qingkailing injection,ceftriaxone sodium for injection,potassium sodium dehydroandrographolide succinate for injection,cefoperazone sodium for injection,cefuroxime sodium for injection,ceftazidime for injection,piperacillin sodium and sulbactam sodium for injection,azithromycin for injection,and Tanreqing injection.The most common system/organ involvements caused by ADR were damage of skin and its appendages(2,453 cases,69.47％),followed by the digestive system damage(361 cases,10.22％)and systemic damage(193 cases,5.47％).Conclusion:The situation and characteristics of ADR in medical institutions in Hezhou are similar to those reported in China.The supervision of medical staff in intravenous drug administration,drug combination,antibacterial drugs and traditional Chinese medicine injection should be strengthened,and the monitoring of ADR by clinical pharmacists should be enhanced,so as to reduce the occurrence of ADR in children and ensure the medication safety.关键词
儿童/药品不良反应/用药安全Key words
children/adverse drug reactions/medication safety分类
药学
