儿科药学杂志2025，Vol.31Issue(4)：39-44,6.DOI:10.13407/j.cnki.jpp.1672-108X.2025.04.009
氨甲环酸在儿童颅缝闭锁手术中安全性和有效性的Meta分析
Meta-Analysis on Efficacy and Safety of Tranexamic Acid in Children with Cramosynostosis Surgery
摘要
Abstract
Objective:To systematically review the efficacy and safety of tranexamic acid in children with craniosynostosis surgery,and to provide evidence-based reference for clinical drug use.Methods:PubMed,EMBase,the Cochrane Library,Web of Science,CNKI,VIP and Wanfang databases were retrieved to collect randomized controlled trials(RCT)of tranexamic acid in children with craniosynostosis surgery.The retrieval time was from the database establishment to Dec.31st,2023.Literature screening and data extraction were performed,the quality of included RCT were evaluated by bias risk assessment tool recommended by Cochrane system evaluator manual,RevMan 5.3 software was used for Meta-analysis.Results:A total of 5 articles were enrolled,including 220 patients.Meta-analysis showed that compared with control group,TXA could significantly reduce intraoperative blood loss(MD=-18.64,95％CI-31.50 to-5.78,P=0.004),perioperative total blood loss(MD=-25.55,95％CI-43.16 to-7.94,P=0.004),intraoperative blood transfusion(red blood cells,MD=-7.70,95％CI-10.74 to-4.66,P＜0.01),perioperative total blood transfusion(red blood cells,MD=-14.24,95％CI-27.00 to-1.48,P=0.03).There was no statistical significance between two groups in the postoperative blood loss,postoperative blood transfusion(red blood cells)and surgical time.Adverse events were reported in 1 study.Conclusion:In pediatric craniosynostosis surgery,TXA can reduce blood loss and blood transfusion compared with placebo or no intervention.Meanwhile,10 mg/kg load dose and 5 mg/(kg·h)continuous infusion dose regimen can be recommended for clinical use.关键词
氨甲环酸/颅缝闭锁手术/儿童/Meta分析Key words
tranexamic acid/craniosynostosis surgery/children/Meta-analysis分类
医药卫生引用本文复制引用
任丹阳,沈建玲,涂彩霞,杨琰茗,谢睿,李云巍,李琳,李惠英..氨甲环酸在儿童颅缝闭锁手术中安全性和有效性的Meta分析[J].儿科药学杂志,2025,31(4):39-44,6.基金项目
昆明市卫生科技人才培养项目,编号2023-SW(技)-19. （技）
