广西医科大学学报2025，Vol.42Issue(2)：268-276,9.DOI:10.16190/j.cnki.45-1211/r.2025.02.015
ACAA1在肝细胞癌中的表达及临床意义
Expression and clinical significance of ACAA1 in hepatocellular carcinoma
摘要
Abstract
Objective:To investigate the abnormal expression and clinical significance of ACAA1 in hepatocellu-lar carcinoma(HCC).Methods:The transcriptional and protein expression levels of HCC tissues and normal liver tissues were analyzed by the TCGA database,and the expression levels of ACAA1 and their correlation with clinical characteristics were compared.The diagnostic potential of ACAA1 for HCC was evaluated using the re-ceiver operating characteristic(ROC)curves.The effects of ACAA1 on HCC were analyzed through cell prolifera-tion and migration assays.Results:Compared with the normal controls,both mRNA and protein expression lev-els of ACAA1 were significantly decreased.Their expression levels were negatively correlated with the age of the patients(P＜0.05)and significantly reduced in the cirrhotic patients compared with the non-cirrhotic HCC pa-tients(P＜0.01).The area under the curve(AUC)for ACAA1 mRNA was 0.936(P＜0.001),with a sensitivity of 90%and specificity of 86.5%.Overexpression of ACAA1 inhibited the proliferation and migration of HCC cells(P＜0.001).Furthermore,ACAA1 expression was negatively correlated with the infiltration of various immune cells,and overexpression of ACAA1 significantly increased the transcriptional level of CD276 in HCC cells(P＜0.001).Conclusion:ACAA1 acts as a tumor suppressor gene in HCC and may serve as a diagnostic and prognos-tic biomarker for HCC,as well as participate in the regulation of the tumor immune microenvironment.关键词
肝细胞癌/生物标志物/免疫细胞浸润/预后Key words
hepatocellular carcinoma/biomarker/immune cell infiltration/prognosis分类
临床医学引用本文复制引用
梁紫渊,罗文奇,莫颖禧,周晓莹..ACAA1在肝细胞癌中的表达及临床意义[J].广西医科大学学报,2025,42(2):268-276,9.基金项目
国家自然科学基金资助项目(No.32260170) （No.32260170）
