广西医科大学学报2025，Vol.42Issue(2)：304-308,5.DOI:10.16190/j.cnki.45-1211/r.2025.02.019
乳酸化修饰在动脉粥样硬化中的研究进展
Research progress on lactylation in atherosclerosis
摘要
Abstract
Atherosclerosis(AS)serves as the primary pathological basis for cardiovascular and cerebrovascular diseases.Lactylation,a novel post-translational modification(PTM)linked to lactate molecules,functions as a critical interface between cellular metabolism and epigenetic regulation.This modification influences diverse pathways to regulate essential biological processes and has been closely associated with disease progression.Emerging evidence suggests that lactylation may participate in the pathogenesis of AS.This paper aims to summa-rize the biological characteristics of lactylation,and then specifically emphasizes the mechanisms by which lacty-lation participates in the development of AS through regulating endothelial cell function,macrophage polariza-tion,and smooth muscle cell senescence.关键词
动脉粥样硬化/乳酸化修饰/心脑血管疾病Key words
atherosclerosis/lactylation/cardiovascular and cerebrovascular diseases分类
医药卫生引用本文复制引用
莫钦,蓝翊宁,秦超..乳酸化修饰在动脉粥样硬化中的研究进展[J].广西医科大学学报,2025,42(2):304-308,5.基金项目
广西自然科学基金重点项目资助(区域高发病专项-广西医科大学)(No.2025GXNSFDA069030) （区域高发病专项-广西医科大学）
广西研究生教育创新计划项目资助(No.YCBZ2024137) （No.YCBZ2024137）
