河北科技大学学报2025，Vol.46Issue(2)：196-206,11.DOI:10.7535/hbkd.2025yx02009
代谢重编程对巨噬细胞极化的影响研究进展
Research progress on the effect of metabolic reprogramming on macrophage polarization
摘要
Abstract
The pathogenesis of inflammatory diseases involves complex cellular cascades within tissues,where macrophages play a pivotal role.These cells exhibit remarkable phenotypic plasticity and can polarize into M1 or M2 types depending on the stage of inflammation to adapt to the microenvironment.Environmental adaptability changes prompt macrophages to undergo metabolic reprogramming,providing necessary energy support for cells to effectively participate in anti-inflammatory responses and regulate inflammatory processes.However,research on metabolic reprogramming in anti-inflammatory therapy remains insufficient.This review systematically described the mechanism of macrophages in inflammation process and the latest research progress on metabolic reprogramming.It pointed out the challenges faced by metabolic reprogramming in treating inflammatory diseases and suggests that future research on macrophage metabolic reprogramming should focus on the following areas:1)exploring the mechanism by which metabolic reprogramming products affect the production of inflammatory cytokines by macrophages;2)conducting an in-depth analysis of the molecular mechanism of metabolic reprogramming in regulating macrophages;3)exploring the effects of individual differences on the regulation of macrophage metabolic pathways and customizing individualized treatment plans based on these differences.关键词
细胞免疫学/炎症反应/巨噬细胞/极化/代谢重编程Key words
cellular immunology/inflammatory response/macrophages/polarization/metabolic reprogramming分类
生物学引用本文复制引用
邵江涛,齐俊愉,韩泽旭,郭学玲,齐奕珂,王英泽..代谢重编程对巨噬细胞极化的影响研究进展[J].河北科技大学学报,2025,46(2):196-206,11.基金项目
国家自然科学基金(81760750) （81760750）
河北省自然科学基金(H2020208018,C2020208023) （H2020208018,C2020208023）
石家庄市重点研发及中小企业创新计划项目(241200253A) （241200253A）
河北科技大学博士科研基金项目(QD2023004) （QD2023004）
