中国当代医药2025，Vol.32Issue(9)：18-21,4.DOI:10.3969/j.issn.1674-4721.2025.09.03
降钙素原、氨基末端B型脑钠肽前体、白蛋白检测对重症慢性阻塞性肺疾病患者疾病转归的预测价值
Predictive value of procalcitonin,N-terminal B-type brain natriuretic peptide precursor and albumin detection for disease prognosis in patients with severe chronic obstructive pulmonary disease
摘要
Abstract
Objective To investigate the predictive value of serum procalcitonin(PCT),N-terminal B-type brain natriuretic peptide precursor(NT-proBNP)and albumin(ALB)in the prognosis of patients with severe chronic obstructive pulmonary disease.Methods The medical records of 60 patients with severe chronic obstructive pulmonary disease admitted to Jiujiang University Affiliated Hospital from August 2021 to September 2023 were retrospectively analyzed,and the patients were di-vided into death group(12 cases)and survival group(48 cases)according to their 28-day disease outcomes.The serum levels of PCT,NT-proBNP and ALB were detected by venous blood samples.The relevant factors affecting the prognosis of patients with severe chronic obstructive pulmonary disease(including gender,age,body mass index,chronic obstructive pulmonary disease course,mechanical ventilation time,PCT,NT-proBNP and ALB levels)were analyzed.The predictive value of serum PCT,NT-proBNP and ALB in the progno-sis of patients with severe chronic obstructive pulmonary disease was analyzed.Results Univariate analysis showed that there were no significant differences in gender,age,body mass index and chronic obstructive pulmonary disease course between two groups(P＞0.05).The mechanical ventila-tion time of the survival group was shorter than that of the death group,and the levels of PCT,NT-proBNP and ALB were lower than those of the death group,with statistical significances(P＜0.05).The results of multivariate analysis showed that increased levels of serum PCT(β=2.972,OR=19.524,95％CI:7.956-47.914,P＜0.001),NT-proBNP(β=0.812,OR=2.251,95％CI:1.456-3.481,P＜0.001),ALB(β=3.135,OR=23.000,95％CI:7.210-73.370,P＜0.001)were inde-pendent risk factors for death in patients with severe chronic obstructive pulmonary disease,while mechanical ventilation time(β=-1.081,OR=0.339,95％CI:0.135-0.849,P=0.021)was independent protective factor for the prognosis of patients with severe chronic obstructive pulmonary disease.Combined detection had the highest predictive value in the prognosis of severe chronic obstructive pulmonary disease(AUC=0.908,sensitivity=0.917,specificity=0.687).The second was ALB,with AUC of 0.856,sensitivity of 0.833 and specificity of 0.750.The AUC of PCT was 0.812,the sensitivity was 0.750,and the specificity was 0.771.The AUC of NT-proBNP was 0.729,the sensitivity was 0.667,and the specificity was 0.604.Conclu-sion The combined detection of serum PCT,NT-proBNP and ALB has high clinical application value in evaluating the prognosis of patients with severe chronic obstructive pulmonary disease.By analyzing the changes of each index level,the development of patients'disease is assessed,providing reliable reference for further diagnosis and treatment,and has high clinical application value.关键词
重症慢性阻塞性肺疾病/降钙素原/氨基末端B型脑钠肽前体/白蛋白/预后Key words
Severe chronic obstructive pulmonary disease/Procalcitonin/N-terminal B-type brain natriuretic peptide precursor/Albumin/Prognosis分类
临床医学引用本文复制引用
刘云云,吴蔚..降钙素原、氨基末端B型脑钠肽前体、白蛋白检测对重症慢性阻塞性肺疾病患者疾病转归的预测价值[J].中国当代医药,2025,32(9):18-21,4.基金项目
江西省卫生健康委科技计划项目(202131087). （202131087）
