中国当代医药2025，Vol.32Issue(9)：73-76,4.DOI:10.3969/j.issn.1674-4721.2025.09.15
香芍颗粒联合替勃龙对围绝经期综合征患者睡眠障碍的影响
Effect of Xiangshao Granules combined with Tibolone on sleep disorders in patients with perimenopausal syndrome
摘要
Abstract
Objective To study the effect of Xiangshao Granules combined with Tibolone on sleep disorders in patients with perimenopausal syndrome.Methods A total of 120 patients with perimenopausal syndrome and sleep disorders admitted to Jiangxi Maternal and Child Health Hospital from June 2022 to June 2024 were selected as the research objects.According to the random number table method,they were divided into control group(60 cases)and observation group(60 cases).The con-trol group was treated with Tibolone,and the observation group was treated with Xiangshao Granules on the basis of the control group.The clinical efficacy of the two groups was compared.The traditional Chinese medicine syndrome score,sex hormone levels(estradiol[E2],luteinizing hormone[LH],follicle-stimulating hormone[FSH]),sleep quality(Pittsburgh sleep quality index[PSQI]),adverse mood(self-rating anxiety scale[SAS],self-rating depression scale[SDS])scores before and after treatment were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P＜0.05).After treatment,the traditional Chi-nese medicine syndrome scores and total scores of the observation group were lower than those of the control group,and the differences were statistically significant(P＜0.05).After treatment,the E2 level of the observation group was higher than that of the control group,and the LH and FSH levels were lower than those of the control group,and the differences were statistically significant(P＜0.05).After treatment,the PSQI,SAS and SDS scores of the observation group were lower than those of the control group,and the differences were statistically significant(P＜0.05).Conclusion Xiangshao Granules com-bined with Tibolone has a significant effect on the improvement of sleep disorders in patients with perimenopausal syndrome,which can reduce clinical symptoms,regulate sex hormone levels,improve sleep quality,and relieve bad emotions,which is worthy of promotion.关键词
香芍颗粒/替勃龙/围绝经期综合征/睡眠障碍/性激素Key words
Xiangshao Granules/Tibolone/Perimenopausal syndrome/Sleep disorders/Sex hormone分类
医药卫生引用本文复制引用
张赟,谢淑琴,张晶,辛思明,舒宽勇,苏家林..香芍颗粒联合替勃龙对围绝经期综合征患者睡眠障碍的影响[J].中国当代医药,2025,32(9):73-76,4.基金项目
江西省中医药管理局科技计划项目(2022B449). （2022B449）
