摘要
Abstract
Objective To investigate the effect of concentration selection of Ropivacaine in combined spinal-epidural anes-thesia combined with intravenous general anesthesia on patients with radical resection of cervical cancer.Methods A total of 90 patients undergoing radical resection of cervical cancer in Jingzhou Third People's Hospital from January 2020 to October 2021 were selected as the research objects,and they were divided into group A and group B according to random number table method,with 45 cases in each group.All patients were given combined spinal-epidural anesthesia with 0.5％Ropivacaine in group A and 0.25％Ropivacaine in group B.The hemodynamics(mean arterial pressure[MAP],heart rate[HR]),pain threshold,oxidation and antioxidant system(malondialdehyde[MDA],superoxide dismutase[SOD])of the two groups were compared at different time points.Results There were no significant differences in HR and MAP levels between the two groups before anesthesia at 10 and 30 min(P＞0.05).The pain thresholds of group A at 1 and 24 h after operation were higher than those of group B,and the differences were statistically significant(P＜0.05).There were no significant dif-ferences in MDA and SOD levels 1 h before anesthesia,1 h after anesthesia and 1 h after operation between the two groups(P＞0.05).Conclusion Different concentrations of Ropivacaine in combined spinal-epidural anesthesia combined with in-travenous general anesthesia in the application of radical resection of cervical cancer,0.5％Ropivacaine early postoperative analgesia is better,but there are no significant differences in hemodynamics,antioxidant aspects.关键词
腰硬联合麻醉/罗哌卡因/宫颈癌根治术/疼痛阈值Key words
Combined spinal-epidural anesthesia/Ropivacaine/Radical resection of cervical cancer/Pain threshold分类
医药卫生
