摘要
Abstract
Objective To observe the efficacy of breviscapine combined with levocarnitine in the treatment of patients with acute viral myocarditis(AVM),and analyze its impact on cardiac function and myocardial injury.Methods Clinical data of 96 patients with AVM were retrospectively analyzed.These patients were divided into a levocarnitine group and a combination group according to the treatment plan,with 48 cases in each group.In addition to conventional therapy received by patients in both groups,the levocarnitine group received levocarnitine treatment,while the combination group received intravenous infusion therapy with breviscapine combined with levocarnitine.Both groups received continuous medication administration for 14 days.The efficacy and adverse reactions between the two groups were compared,as well as cardiac function indexes[LVEF,stroke volume(SV)and cardiac output(CO)],myocardial injury markers[cTn I,creatine kinase MB(CK-MB),lactate dehydrogenase(LDH),aspartate aminotransferase(AST)and creatine kinase],inflammatory factors,and oxidative stress indicator levels before and after treatment.Results The total effective rate of the combination group was higher than that of the levocarnitine group(91.67%vs.70.83%,P<0.05).Compared with the levocarnitine group,the LVEF,SV and CO in the combination group were increased after treatment;serum cTn I,CK-MB,LDH,AST,creatine kinase,interleukin-6 and tumor necrosis factor-α(TNF-α)levels in the combination group after treatment were reduced,while the level of interleukin-4 was increased(all P<0.05).Compared with the levocarnitine group,serum superoxide dismutase(SOD)level in the combination group increased,while the advanced oxidation protein products(AOPP)and malondialdehyde levels reduced after treatment(all P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Breviscapine combined with levocarnitine could significantly improve the therapeutic effect on AVM patients,significantly ameliorate cardiac function,which may be related to the inhibition of inflammation-oxidative stress response,and has good safety.关键词
急性病毒性心肌炎/灯盏花素/左卡尼汀/疗效/心功能Key words
acute viral myocarditis/breviscapine/levocarnitine/therapeutic effect/cardiac function分类
临床医学
