摘要
Abstract
Objective To investigate the predictive value of carotid artery ultrasound blood flow parameters and serum cystatin C(CysC)level for the prognosis of patients with ischemic stroke(IS).Methods Retrospective analysis was performed on 128 patients with IS(observation group).According to the degree of carotid artery stenosis,the observation group was divided into mild(n=32),moderate(n=66)and severe(n=30)subgroups,while 64 healthy volunteers participating in physical examinations during the same period were selected as the control group.We compared the carotid artery ultrasound blood flow parameters including peak systolic velocity(PSV)and end-diastolic velocity(EDV),and serum CysC level between the two groups,and among the patients with different degrees of carotid artery stenosis.The observation group was given conventional treatment,and divided into poor prognosis subgroup(n=42)and good prognosis subgroup(n=86)according to the prognosis within 3 months after treatment.The carotid artery ultrasound blood flow parameters and serum CysC level were compared between these patients with different prognosis before and after the treatment.The influencing factors of poor prognosis were analyzed.The predictive efficiency of carotid artery ultrasound blood flow parameters and serum CysC on the prognosis was evaluated.Results The PSV,EDV and serum CysC level in the observation group before treatment were all significantly higher than those in the control group(all P<0.01).With the aggravation of carotid artery stenosis,the PSV,EDV and serum CysC level in the observation group before treatment showed an upward trend(all P<0.01).The PSV,EDV and serum CysC level of the patients with poor prognosis were significantly higher than those of the patients with good prognosis one month after treatment(all P<0.01);increased PSV,EDV and serum CysC level were risk factors for poor prognosis(all P<0.05).The AUC value of the combined prediction of PSV,EDV and CysC one month after treatment was better than that of single index prediction for the prognosis 3 months after treatment(P<0.05).Conclusion The PSV,EDV and serum CysC level in patients with IS are significantly elevated,and are closely related to the degree of carotid artery stenosis.Combined detection of the three indexes could improve the predictive efficiency of the prognosis of IS patients.关键词
缺血性脑卒中/颈动脉超声/胱抑素C/预后/预测模型Key words
ischemic stroke/carotid artery ultrasound/cystatin C/prognosis/prediction model分类
医药卫生
