实用心电与临床诊疗2025，Vol.34Issue(2)：188-193,6.DOI:10.13308/j.issn.2097-5716.2025.02.007
椎动脉血流动力学参数联合血清CGRP检测对颈性眩晕患者疗效的评估价值
Assessment value of vertebral artery hemodynamic parameters combined with serum CGRP detection for therapeutic effect in patients with cervical vertigo
摘要
Abstract
Objective To observe the changes in vertebral artery hemodynamic parameters by ultrasonic examination and serum calcitonin gene-related peptide(CGRP)level in patients with cervical vertigo,and to explore their assessment value for the therapeutic effect on cervical vertigo.Methods A retrospective analysis was conducted on 108 patients with cervical vertigo(designated as a study group),while 36 healthy volunteers were selected during the same period as a control group.The vertebral artery hemodynamic parameters[systolic maximum blood flow velocity(Vmax)of the left vertebral artery(LVA),right vertebral artery(RVA),and basilar artery(BA)],and serum CGRP level were compared between the two groups.The LVA-Vmax,RVA-Vmax,BA-Vmax,and serum CGRP level in patients with different severities of vertigo were compared in the study group.The study group received routine treatment,and was divided into an effective subgroup with 74 cases and an ineffective subgroup with 34 cases based on the therapeutic effect after one month of treatment.The clinical data,and LVA-Vmax,RVA-Vmax,BA-Vmax and serum CGRP level before and after treatment were compared between the two subgroups.The influencing factors of efficacy were analyzed;the values of LVA-Vmax,RVA-Vmax,BA-Vmax and serum CGRP level in assessing the treatment efficacy were explored.Results The LVA-Vmax,RVA-Vmax,BA-Vmax,and serum CGRP level in the study group were all lower than those in the control group(all P<0.01).The levels of LVA-Vmax,RVA-Vmax,BA-Vmax,and serum CGRP in the study group were ranked in ascending order as follows:patients with severe vertigo<those with moderate vertigo<those with mild vertigo(all P<0.05).After one month of treatment,the LVA-Vmax,RVA-Vmax,BA-Vmax,and serum CGRP level in the ineffective subgroup were all lower than those in the effective subgroup(all P<0.01).Multivariate Logistic regression analysis showed that age and disease duration were risk factors for treatment efficacy,while LVA-Vmax,RVA-Vmax,BA-Vmax,and serum CGRP level were protective factors for treatment efficacy(all P<0.05).After one month of treatment,the AUC value of the combined LVA-Vmax,RVA-Vmax,BA-Vmax,and serum CGRP level for assessing treatment efficacy was greater than that of any individual indicator(all P<0.01).Conclusion Patients with cervical vertigo exhibit reduced ultrasonic examination parameters including LVA-Vmax,RVA-Vmax and BA-Vmax,and serum CGRP level,which are associated with the severity of vertigo and treatment efficacy.Combined detection of these parameter levels offers certain assessment value for treatment efficacy.关键词
颈性眩晕/椎动脉血流动力学参数/降钙素基因相关肽/椎动脉/基底动脉Key words
cervical vertigo/vertebral artery hemodynamic parameter/calcitonin gene-related peptide/vertebral artery/basal artery分类
医药卫生引用本文复制引用
晁胜艳,陈洁如,谢志飞,韩如冰..椎动脉血流动力学参数联合血清CGRP检测对颈性眩晕患者疗效的评估价值[J].实用心电与临床诊疗,2025,34(2):188-193,6.基金项目
河南省医学科技攻关联合共建项目(LHGJ20195199) （LHGJ20195199）
