摘要
Abstract
Objective To investigate the correlation of the levels of serum iron regulatory protein 2(IRP2),cyclin-dependent kinase inhibitor 1A(CDKN1A)and human alveolar typeⅡcell surface antigen(KL-6)with the pulmonary function and clinical prognosis of patients with chronic obstructive pulmonary disease(COPD).Methods A retrospective study was conducted on 136 patients with COPD as a observation group.A total of 136 healthy individuals who had undergone physical examinations during the same period were selected as a control group.The levels of serum IRP2,CDKN1A,and KL-6 were compared between the two groups and among patients with different prognoses.The pulmonary function indicators[the ratio of forced expiratory volume in the first second(FEV1)to forced vital capacity(FVC),and FEV1 as a percentage of the predicted value(FEV1%pred)]were compared between the two groups.The correlation of serum IRP2,CDKN1A and KL-6 levels with FEV1%pred,FEV1/FVC and the prognosis was analyzed;the predictive value of combined detection of various serum indicators was analyzed.Results The levels of serum IRP2,CDKN1A,and KL-6 in the observation group were significantly higher than those in the control group(all P<0.01).The FEV1%pred and FEV1/FVC in the observation group were significantly lower than those in the control group(all P<0.01).The levels of serum IRP2,CDKN1A,and KL-6 in patients with poor prognosis were significantly higher than those in patients with good prognosis(all P<0.01).The levels of serum IRP2,CDKN1A,and KL-6 were negatively correlated with FEV1%pred and FEV1/FVC,while they were positively correlated with patients'prognoses(all P<0.01).The AUC value of the combined prediction of serum IRP2,CDKN1A,and KL-6 levels for poor prognosis in patients with COPD was 0.937,with a Youden index of 0.775,and the sensitivity and specificity were 94.12%and 83.33%,respectively;the differences were statistically significant(all P<0.01).Conclusion The levels of serum IRP2,CDKN1A,and KL-6 vary with the pulmonary function and clinical prognosis of COPD patients;there is a strong correlation between them.The combined detection of these indicators could provide some references for prognosis prediction in clinical practice.关键词
慢性阻塞性肺疾病/铁调节蛋白2/细胞周期蛋白依赖性激酶抑制剂1A/人Ⅱ型肺泡细胞表面抗原/肺功能/预后/相关性Key words
chronic obstructive pulmonary disease/IRP2/CDKN1A/KL-6/pulmonary function/prognosis/correlation分类
医药卫生
