实用心电与临床诊疗2025，Vol.34Issue(2)：272-277,6.DOI:10.13308/j.issn.2097-5716.2025.02.023
人类ether-à-go-go相关基因在药物诱导性长QT间期综合征发生发展中的作用
Role of human ether-à-go-go related gene in occurrence and development of drug-induced long QT syndrome
摘要
Abstract
The rapid activating delayed rectifier potassium channel encoded by human ether-à-go-go related gene(hERG)subfamily H member 2(KCNH2)is the target of many drugs that produce unintended cardiotoxicity.Drug-induced long QT syndrome(diLQTS)is a pathological condition of prolonged QT interval induced by one or more off-target interactions of various antiarrhythmic drugs,antibiotics,antihistamines,antipsychotics,and vasodilators.Corrected QT interval(QTc)>450 ms in males and>460 ms in females is one of clinical manifestations of diLQTS electrocardiogram.Such acquired long QT syndrome is prone to induce torsades de pointes,which further progresses to ventricular fibrillation and even sudden cardiac death.This review summarizes the role of hERG in the occurrence and development of diLQTS from aspects of chemical structure,electrocardiography,biology,electrophysiology and molecular biology.关键词
人类ether-à-go-go相关基因/药物诱导/长QT间期综合征/QT间期Key words
human ether-à-go-go related gene/drug-induced/long QT syndrome/QT interval分类
医药卫生引用本文复制引用
唐闻,廉姜芳,宋勇飞..人类ether-à-go-go相关基因在药物诱导性长QT间期综合征发生发展中的作用[J].实用心电与临床诊疗,2025,34(2):272-277,6.基金项目
国家自然科学基金资助项目(81870255) （81870255）
浙江省自然科学基金资助项目(LY21H020001,LQQ20H160001) （LY21H020001,LQQ20H160001）
浙江省医药卫生科技项目(2021KY306) （2021KY306）
宁波市自然科学基金资助项目(2021J296) （2021J296）
