摘要
Abstract
Radiation-induced skin injury(RISI)is a common complication during the process of tumor radiotherapy,with nearly 90%of radio therapy patients experiencing moderate to severe skin adverse reactions.In severe cases,it may result in treatment interruption or adjustment of therapeutic regimen.However,the current standard of care for acute RISI remains to be improved.Traditional natural Chinese medicines are not only cost-effective,but also can promote tissue regeneration in patients with radiation-induced skin damage.phellodendron amurense(Huang Bai)and coptis chinensis(Huang Lian)as traditional natural Chinese medicines,possess anti-inflammatory,antibacterial,antioxidant,and wound-healing properties,which have attracted extensive attention in the treatment of RISI in recent years.They primarily exert their anti-inflammatory properties by regulating the nuclear factor κB pathway to reduce the levels of inflammatory factors,leverage their inherent anti-inflammatory properties to prevent oxidative stress and inflammatory responses,thereby offering protection and control against RISI.This article reviews the mechanisms underlying RISI,the main active components of phellodendron amurense and coptis chinensis,their pharmacological mechanisms of action,and the research progress on their application,aiming to provide theoretical references for the prevention and protection against RISI.关键词
放射治疗/皮肤损伤防护/天然药物/黄柏/黄连Key words
radiotherapy/prevention and protection against skin injury/natural medicine/phellodendron amurense/coptis chinensis分类
医药卫生
