检验医学与临床2025，Vol.22Issue(8)：1009-1013,5.DOI:10.3969/j.issn.1672-9455.2025.08.001
儿童社区获得性肺炎患儿嗜血杆菌属感染及共感染病原谱的特征分析
Characteristic analysis of Haemophilus infection and co-infection pathogen spectrum in children with community acquired pneumonia
摘要
Abstract
Objective To analyze the characteristic of Haemophilus infections and co-infection pathogen spectrum in children with community-acquired pneumonia(CAP).Methods A retrospective analysis was conducted on the results of sputum bacterial cultures from 1 187 children with CAP admitted to Xinjiang Pro-duction and Construction Corps Hospital from October 1,2023 to June 30,2024.The detection rates of Hae-mophilus infections were compared across different genders,age groups,and seasons.Additionally,the antibi-otic resistance patterns and characteristics of the co-infection pathogen spectrum were evaluated.Results Sputum culture results from 1 187 children with CAP revealed that the predominant isolated pathogen was Haemophi-lus parainfluenzae,with a detection rate of 15.67%,followed by Haemophilus influenzae at 10.36%.From October 1,2023,the peak detection period for Haemophilus parainfluenzae positivity was weeks 1-17,corre-sponding to October 1,2023 to January 27,2024(autumn and winter),with the highest peak at week 9(40.00%).For Haemophilus influenzae,the peak detection period was weeks 1-15,from October 1,2023 to January 13,2024(autumn and winter),with the highest peak at week 1(35.00%).Starting from February 2024(spring),the positive detection rates of Haemophilus showed a declining trend.The positive detection rate of Haemophilus influenzae was significantly higher in children aged 13-<18 years compared with those aged 0-<7 years and 7-<13 years(P<0.05).The positive detection rates of both Haemophilus parainflu-enzae and Haemophilus influenzae were significantly higher in autumn and winter than in spring and summer(P<0.05).The positive detection rates of Haemophilus parainfluenzae and Haemophilus influenzae to β-lac-tamases were 80.65%and 92.68%respectively.The results of drug susceptibility test showed that the drug resistance rates of Haemophilus influenzae and parainfluenza to ampicillin were the highest among the 11 anti-biotics,which were 79.03%and 94.31%respectively.The positive detection rate of Hemophilus paraininflu-enzae infection alone was 13.82%,and the positive detection rate of Hemophilus paraininfluenzae infection combined with more than two pathogens was 21.21%.The positive detection rate of Hemophilus influenzae infection alone was 9.35%,and the positive detection rate of respiratory syncytial virus infection was the high-est,which was 19.05%.Conclusion During the autumn and winter seasons of 2023-2024,an epidemic of Haemophilus infections may have occurred among children with CAP,with a decline in prevalence observed in the spring.Additionally,Haemophilus infections were prone to co-infections with viral pathogens.关键词
社区获得性肺炎/流感嗜血杆菌/副流感嗜血杆菌/共感染/病原谱Key words
community acquired pneumonia/Haemophilus influenzae/Haemophilus parainfluenzae/co-infection/pathogen spectrum分类
医药卫生引用本文复制引用
史茜,伊贝拜汗·买买提,查贺飞,张新..儿童社区获得性肺炎患儿嗜血杆菌属感染及共感染病原谱的特征分析[J].检验医学与临床,2025,22(8):1009-1013,5.基金项目
国家临床重点专科建设项目[兵财社(2023)16号] （2023）
兵团重点领域科技攻关计划项目(2024AB072) （2024AB072）
新疆生产建设兵团医院科技计划项目(2024008). （2024008）
