检验医学与临床2025，Vol.22Issue(8)：1024-1028,5.DOI:10.3969/j.issn.1672-9455.2025.08.004
血清CXCL8、sFRP5水平与心房颤动合并心力衰竭患者心功能的关系及其在临床诊断中的意义
The relationship between serum CXCL8,sFRP5 levels with cardiac function in patients with atrial fibrillation complicated with heart failure and their significance in the clinical diagnosis
摘要
Abstract
Objective To analyze the relationship between serum levels of CXC chemokine ligand 8(CXCL8)and secreted frizzled related protein 5(sFRP5)with cardiac function in patients with atrial fibrilla-tion complicated with heart failure and their significance in the clinical diagnosis.Methods A total of 106 pa-tients with atrial fibrillation admitted to Tangshan Central Hospital from January 2022 to October 2023 were selected as the study objects and divided into failure group(36 cases)and non-failure group(70 cases)accord-ing to whether they were complicated with heart failure.Left ventricular ejection fraction(LVEF),left atrial diameter(LAD)and serum levels of CXCL8 and sFRP5 in patients were detected.Pearson correlation analysis was used to analyze the correlation between serum CXCL8,sFRP5 levels and LVEF,LAD in the failure group.Spearman correlation analysis was used to analyze the correlation between serum CXCL8 and sFRP5 levels and New York heart association(NYHA)heart function grades classification in the failure group.Mult-ivariate Logistic regression analysis was used to analyze the influencing factors of atrial fibrillation complicated with heart failure.Receiver operating characteristic(ROC)curves were plotted to analyze the diagnostic value of serum CXCL8 and sFRP5 for atrial fibrillation complicated with heart failure.Results The LVEF and sFRP5 in failure group were lower than those in non-failure group,the LAD and serum CXCL8 level in failure group were higher than those in non-failure group,and the differences were statistically significant(P<0.05).The comparison of serum CXCL8 levels in patients with different NYHA heart function grades in the failure group showed that Ⅰ-Ⅱ grade<Ⅲ grade<Ⅳ grade,and any pairwise comparison showed statisti-cally significant differences(P<0.05).The comparison of serum sFRP5 levels among patients with different NYHA heart function grades in the failure group showed that Ⅰ-Ⅱ grade>Ⅲ grade>Ⅳ grade,and any pairwise comparison showed statistically significant differences(P<0.05).The Pearson correlation analysis results showed that the serum CXCL8 level in the failure group was negatively correlated with LVEF(r=-0.307,P=0.001)and positively correlated with LAD(r=0.445,P<0.001).The serum sFRP5 level in the failure group was positively correlated with LVEF(r=0.266,P=0.006)and negatively correlated with LAD(r=-0.316,P<0.001).Spearman correlation analysis results showed that the NYHA heart function grades in the failure group was positively correlated with serum CXCL8 levels(rs=0.328,P<0.001)and negatively correlated with serum sFRP5 levels(rs=-0.367,P<0.001).Multivariate Logistic regression a-nalysis showed that increased serum CXCL8 level and decreased sFRP5 level were risk factors for atrial fibril-lation complicated with heart failure(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of serum CXCL8 and sFRP5 combined in the diagnosis of atrial fibrillation complicated with heart fail-ure was 0.907,which was larger than the AUC of CXCL8 and sFRP5 alone(Z=2.254,2.116;P=0.024,0.034).Conclusion Elevated serum CXCL8 level and decreased serum sFRP5 level are risk factors for atrial fibrillation patients complicated with heart failure,which are related to cardiac function indexes and NYHA heart function classification of patients.Combined detection of CXCL8 and sFRP5 can be used to assist the di-agnosis of atrial fibrillation complicated with heart failure,and the diagnostic performance is good.关键词
心房颤动/心力衰竭/CXC趋化因子配体8/分泌型卷曲相关蛋白5/临床意义Key words
atrial fibrillation/heart failure/CXC chemokine ligand 8/secreted frizzled related pro-tein 5/clinical significance分类
医药卫生引用本文复制引用
侯杰,刘勇,姚海涛,于佳,许庆明..血清CXCL8、sFRP5水平与心房颤动合并心力衰竭患者心功能的关系及其在临床诊断中的意义[J].检验医学与临床,2025,22(8):1024-1028,5.基金项目
河北省医学科学研究课题计划项目(20211296). （20211296）
