检验医学与临床2025，Vol.22Issue(8)：1029-1033,5.DOI:10.3969/j.issn.1672-9455.2025.08.005
血清sEndoglin、ESM-1、ADAM10对妊娠期高血压疾病患者发生不良妊娠结局的诊断价值
Diagnostic value of serum sEndoglin,ESM-1 and ADAM10 for adverse pregnancy outcomes in patients with hypertensive disorders complicating pregnancy
摘要
Abstract
Objective To analyze the diagnostic value of serum soluble cell endothelial glycoprotein(sEn-doglin),endothelial cell specific molecule-1(ESM-1)and disintegrin and metalloproteinase 10(ADAM10)for adverse pregnancy outcomes in patients with hypertensive disorder complicating pregnancy(PIH).Methods A total of 154 PIH patients admitted to the hospital from October 2021 to December 2023 were se-lected as the research subjects.According to the pregnancy outcome of PIH patients,they were divided into adverse pregnancy outcome group(41 cases)and good pregnancy outcome group(113 cases),and 120 healthy pregnant women who underwent physical examination in the hospital during the same period were selected as the control group.Pearson correlation analysis was used to analyze the correlation between serum sEndoglin,ESM-1 and ADAM10 levels in PIH patients.Multivariate Logistic regression was used to analyze the influen-cing factors of adverse pregnancy outcomes in PIH patients.Receiver operating characteristic(ROC)curve was used to analyze the diagnostic efficacy of serum sEndoglin,ESM-1 and ADAM10 for adverse pregnancy outcomes in PIH patients.Results The levels of serum sEndoglin,ESM-1 and ADAM10 in the adverse preg-nancy outcome group and the good pregnancy outcome group were higher than those in the control group,and the levels of serum sEndoglin,ESM-1 and ADAM10 in the adverse pregnancy outcome group were higher than those in the good pregnancy outcome group(P<0.05).Pearson correlation analysis showed that serum sEn-doglin and ESM-1 levels were positively correlated with ADAM10 levels in PIH patients(P<0.001),and ser-um ESM-1 levels were also positively correlated with sEndoglin levels(P<0.001).The proportions of pa-tients with pre-pregnancy body mass index(BMI)≥24 kg/m2 and gestational age at delivery<36 weeks in the adverse pregnancy outcome group were higher than those in the good pregnancy outcome group,and the differences were statistically significant(P<0.05).Multivariate Logistic regression analysis showed that pre-pregnancy BMI≥24 kg/m2,gestational age at delivery<36 weeks and increased serum sEndoglin,ESM-1,and ADAM10 levels were risk factors for adverse pregnancy outcomes in PIH patients(P<0.05).The results of ROC curve analysis showed that the area under the curve(AUC)of the combined diagnosis of three indica-tors for adverse pregnancy outcomes in PIH patients was 0.867,which was greater than the AUC of serum sEndoglin,ESM-1 and ADAM10 alone(Z=4.068,4.168,3.156,P<0.05).Conclusion The serum levels of sEndoglin,ESM-1 and ADAM10 are increased in PIH patients and are related to the occurrence of adverse pregnancy outcomes.The combination of the 3 indicators has certain diagnostic efficacy for the occurrence of adverse pregnancy outcomes in PIH patients.关键词
妊娠期高血压疾病/妊娠结局/可溶性细胞内皮糖蛋白/内皮细胞特异性分子-1/解整合素金属蛋白酶10Key words
hypertensive disorder complicating pregnancy/pregnancy outcome/soluble cell endothelial glycoprotein/endothelial cell specific molecule-1/disintegrin and metalloproteinase 10分类
医药卫生引用本文复制引用
杨丽佳,高义军,周高英,邵郅强,郭佳..血清sEndoglin、ESM-1、ADAM10对妊娠期高血压疾病患者发生不良妊娠结局的诊断价值[J].检验医学与临床,2025,22(8):1029-1033,5.基金项目
河北省唐山市卫生健康委员会科研项目(20231855). （20231855）
