检验医学与临床2025，Vol.22Issue(8)：1034-1038,5.DOI:10.3969/j.issn.1672-9455.2025.08.006
加味黄芪桂枝五物汤联合常规化疗治疗胃癌患者的疗效及对血清ITGβ6、Notch-3水平的影响
Clinical efficacy of Jiawei Huangqi Guizhi Wuwu decoction combined with conventional chemotherapy in patients with gastric cancer and its effect on serum ITGβ6 and Notch-3 levels
摘要
Abstract
Objective To investigate the clinical efficacy of Jiawei Huangqi Guizhi Wuwu decoction com-bined with conventional chemotherapy in patients with gastric cancer and its effect on serum human integrin β6(ITGβ6)and Notch homology 3(Notch-3)levels.Methods A total of 130 patients with advanced gastric cancer admitted to the hospital from January 2019 to December 2023 were selected as the research subjects.According to the random number table method,the patients were divided into the observation group and the control group,with 65 cases in each group.The control group was treated with conventional chemotherapy,and the observation group was treated with Jiawei Huangqi Guizhi Wuwu decoction combined with conven-tional chemotherapy.The clinical efficacy,Traditional Chinese Medicine(TCM)Syndrome scores,adverse re-actions,tumor markers,immune function,serum ITGβ6 and Notch-3 levels were compared between the two groups.Results The objective response rate(ORR)and disease control rate(DCR)of the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05).After treatment,the epigastric distension and pain,appetite deprivation,hiccup and fatigue,pale tongue coating scores,as well as the levels of serum carcinoembryonic antigen(CEA),cytokeratin(CK),carbohydrate anti-gen 199(CA199),ITGβ6,Notch-3 and CD8+T lymphocytes proportion in the two groups were lower than those before treatment.The proportions of CD4+T lymphocytes,CD3+T lymphocytes and CD4+T lympho-cytes/CD8+T lymphocytes ratio in the two groups were higher than before treatment,and the differences were statistically significant(P<0.05).After treatment,the scores of epigastric distension and pain,appetite deprivation,hiccup and fatigue,pale tongue coating,and the levels of serum CEA,CK,CA199,ITGβ6,Notch-3 and the proportion of CD8+T lymphocytes in the observation group were lower than those in the control group,and the proportions of CD4+T lymphocytes,CD3+T lymphocytes and CD4+T lymphocytes/CD8+T lymphocytes ratio in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The Jiawei Huangqi Guizhi Wuwu decoction has a good effect on gastric cancer patients,and it can improved traditional Chinese medicine syndrome,and it can reduced tumor marker levels,enhanced immune function,inhibited serum ITGβ6 and Notch-3 expression lev-els,and it has good treatment safety.关键词
胃癌/加味黄芪桂枝五物汤/人整合素β6/Notch同源物3/临床疗效/免疫功能Key words
gastric cancer/Jiawei Huangqi Guizhi Wuwu decoction/human integrin β6/notch homo-log 3/clinical effect/immune function分类
医药卫生引用本文复制引用
张倩,张萍静,刘奕彤,郑明明..加味黄芪桂枝五物汤联合常规化疗治疗胃癌患者的疗效及对血清ITGβ6、Notch-3水平的影响[J].检验医学与临床,2025,22(8):1034-1038,5.基金项目
新疆维吾尔自治区巴音郭楞蒙古自治州科学技术研究计划项目(2021075). （2021075）
