检验医学与临床2025，Vol.22Issue(8)：1112-1115,4.DOI:10.3969/j.issn.1672-9455.2025.08.020
妊娠糖尿病合并子痫前期患者血清瘦素、可溶性肾素受体、叶酸水平与疾病严重程度及妊娠结局的关系
Relationship between serum leptin,soluble renin receptor and folate level with disease severity and pregnancy outcome in patients with gestational diabetes mellitus complicating preeclampsia
摘要
Abstract
Objective To explore the relationship between the levels of serum leptin,soluble prorenin re-ceptor[s(P)RR]and folic acid with the disease severity and pregnancy outcome in the patients with gestation-al diabetes mellitus(GDM)complicating preeclampsia(PE).Methods A total of 106 patients with GDM complicating PE delivered in this hospital from June 2021 to June 2023 were selected as the observation group and divided into the GDM complicating mild PE subgroup(n=53)and GDM complicating severe PE sub-group(n=53)according to the severity of PE;other 110 patients with simple GDM during the same period were selected as the control group.The levels of serum leptin and s(P)RR in the subjects were detected by the enzyme-linked immunosorbent assay,and the level of serum folic acid was detected by automatic chemilumi-nescence immunoanalyzer;the pregnancy outcomes of the patients with GDM complicating PE were recorded,and the levels of serum leptin,s(P)RR and folic acid were compared among the groups.Results Compared with the control group,the levels of serum leptin and s(P)RR in the observation group were increased,the level of folic acid was decreased,and the differences were statistically significant(P<0.05).Compared with the GDM complicating mild PE subgroup,the levels of serum leptin and s(P)RR in the GDM complicating severe PE subgroup were increased,the level of folic acid was decreased,and the differences were statistically significant(P<0.05).Compared with the patients without preterm birth,postpartum hemorrhage,neonatal asphyxia,neonatal hypoglycemia and fetal growth restriction,the levels of serum leptin and s(P)RR in the patients with preterm birth,postpartum hemorrhage,neonatal asphyxia,neonatal hypoglycemia and fetal growth restriction were increased,the level of folic acid was decreased,and the differences were statistically significant(P<0.05).Conclusion The levels of serum leptin,s(P)RR and folic acid in the patients with GDM complicating PE are abnormal,moreover which have a certain relationship with the severity of the disease and pregnancy outcome.关键词
妊娠糖尿病/子痫前期/瘦素/可溶性肾素受体/叶酸Key words
gestational diabetes mellitus/preeclampsia/leptin/soluble pro-renin receptor/folic acid分类
临床医学引用本文复制引用
刘萱,曹君阳,张蒙蒙..妊娠糖尿病合并子痫前期患者血清瘦素、可溶性肾素受体、叶酸水平与疾病严重程度及妊娠结局的关系[J].检验医学与临床,2025,22(8):1112-1115,4.基金项目
2024年度河北省医学科学研究课题计划项目(20241283). （20241283）
