检验医学与临床2025，Vol.22Issue(8)：1127-1132,6.DOI:10.3969/j.issn.1672-9455.2025.08.023
血清LXA4、HDAC6水平与慢性阻塞性肺疾病急性加重期患者肺功能及预后的关系
Association of serum LXA4 and HDAC6 levels with lung function and prognosis in patients with acute exacerbation of chronic obstructive pulmonary disease
摘要
Abstract
Objective To investigate the relationship between serum lipoxin A4(LXA4),histone deacety-lase 6(HDAC6)and lung function and prognosis in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 235 AECOPD patients in Handan 285th Hospital from May 2021 to June 2024 were selected as the AECOPD group,and 181 stable chronic obstructive pulmonary disease(COPD)patients in Handan 285th Hospital during the same period were selected as the SCOPD group and 268 healthy volunteers who underwent physical examination in Handan 285th Hospital were selected as the control group.According to the prognosis of AECOPD patients after treatment,they were divided into good prognosis group and poor prognosis group.Serum LXA4 and HDAC6 levels were detected by enzyme-linked immunosorbent assay.Peak expiratory flow(PEF),forced vital capacity(FVC)and forced expiratory volume in one second(FEV1)were detected by pulmonary function detector,and FEV1/FVC ratio was calcu-lated.Pearson correlation analysis was used to analyze the correlation between serum LXA4,HDAC6 levels and pulmonary function indexes,disease duration,COPD assessment test(CAT)score in the poor prognosis group.Multivariate Logistic regression was used to analyze the influencing factors of poor prognosis in AECO-PD patients.The receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of serum LXA4 and HDAC6 for poor prognosis in AECOPD patients.Results The course of disease in AECO-PD group was longer than that in SCOPD group,CAT score and serum HDAC6 level were higher than those in SCOPD group,while FEV1,FVC,FEV1/FVC ratio,PEF and serum LXA4 level were lower than those in SCOPD group,the differences were statistically significant(P<0.05).The control group had a significantly higher serum LXA4 level and a significantly lower serum HDAC6 level than those in the SCOPD and AECO-PD groups,and the differences were statistically significant(P<0.05).A total of 173 patients were included in the good prognosis group and 62 patients were included in the poor prognosis group.The FEV1,FVC,FEV1/FVC ratio,PEF and serum LXA4 levels in the poor prognosis group were lower than those in the good prognosis group,while the disease duration in the poor prognosis group was longer than that in the good prog-nosis,and CAT score and serum HDAC6 in the poor prognosis group level were higher than those in the good prognosis group,and the differences were statistically significant(P<0.05).Pearson correlation analysis showed that the serum LXA4 level in the poor prognosis group was negatively correlated with the course of disease and CAT score(P<0.05),and positively correlated with FEV1,FVC,FEV1/FVC ratio,and PEF(P<0.05).In the poor prognosis group,the serum HDAC6 level was positively correlated with the course of disease and CAT score(P<0.05),and negatively correlated with FEV1,FVC,FEV1/FVC ratio,and PEF(P<0.05).Multivariate Logistic regression analysis showed that CAT score,increased serum HDAC6 level and decreased serum LXA4 level were risk factors for poor prognosis in AECOPD patients(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of serum LXA4 and HDAC6 combined to predict poor prognosis of AECOPD patients was 0.924,which was larger than the AUC of serum LXA4 and HDAC6 alone(Z=5.172,3.025;P<0.05).Conclusion The serum LXA4 level is decreased and HDAC6 level is in-creased in AECOPD patients with poor prognosis.The serum LXA4 and HDAC6 levels are correlated with lung function indexes,and the combined prediction has certain clinical significance.关键词
慢性阻塞性肺疾病急性加重期/脂氧素A4/组蛋白去乙酰化酶6/肺功能/预后/预测价值Key words
acute exacerbation of chronic obstructive pulmonary disease/lipoxin A4/histone deacety-lase 6/pulmonary function/prognosis/predictive value分类
临床医学引用本文复制引用
常秀明,柴书坤,沈丽晓..血清LXA4、HDAC6水平与慢性阻塞性肺疾病急性加重期患者肺功能及预后的关系[J].检验医学与临床,2025,22(8):1127-1132,6.基金项目
河北省卫生健康委员会资助项目(20241354). （20241354）
