检验医学与临床2025，Vol.22Issue(8)：1133-1137,5.DOI:10.3969/j.issn.1672-9455.2025.08.024
血清NOX-4、STAT3在肺炎新生儿发生细菌性感染的早期诊断及治疗评价中的作用
Role of serum NOX-4 and STAT3 in early diagnosis and treatment evaluation of bacterial infection in neonates with pneumonia
李华兵 1余少华 1李林1
作者信息
- 1. 四川省广安市广安区人民医院儿科,四川 广安 638550
- 折叠
摘要
Abstract
Objective To investigate the role of nicotinamide adenine dinucleotide phosphate oxidase 4(NOX-4)and signal transducer and activator of transcription 3(STAT3)in the early diagnosis and treatment evaluation of bacterial infection in neonates with pneumonia.Methods A total of 150 children with neonatal pneumonia who were treated in this hospital from August 2021 to August 2023 were selected as the study ob-jects.According to whether the children had bacterial infection,they were divided into bacterial pneumonia group(86 cases)and non-bacterial pneumonia group(64 cases),and the efficacy of anti-infection treatment for 7 days was analyzed.Serum NOX-4 and STAT3 levels were detected by enzyme-linked immunosorbent as-say.Pearson method was applied to analyze the correlation between serum NOX-4 and STAT3 levels of bacte-rical infection in neonates with pneumonia.Multivariate Logistic regression was applied to analyze the influen-cing factors of bacterial infection in neonates with pneumonia.Receiver operating characteristic(ROC)curve was applied to analyze the diagnostic value of serum NOX-4 and STAT3 levels for neonatal with bacterial pneumonia.Results The levels of serum C-reactive protein(CRP),NOX-4,STAT3 and heart rate in bacterial pneumonia group were significantly higher than those in non-bacterial pneumonia group,and the differences were statistically significant(P<0.05).Serum NOX-4 and STAT3 levels in neonates with poor efficacy of bacterial pneumonia were higher than those in neonates with good efficacy of bacterial pneumonia,and serum NOX-4 and STAT3 levels in neonates with poor efficacy of non-bacterial pneumonia were higher than those in neonates with good efficacy of non-bacterial pneumonia,the differences were statistically significant(P<0.05).Pearson correlation analysis showed that there was a positive correlation between serum NOX-4 level and STAT3 level of bacterial infection in neonates with pneumonia(r=0.421,P<0.05).Multivariate Logis-tic regression analysis showed that increased heart rate,CRP,serum NOX-4 and STAT3 levels were risk fac-tors for bacterial infection in neonates with pneumonia(P<0.05).ROC curve analysis results showed that the area under the curve(AUC)of serum NOX-4 and STAT3 combined in the diagnosis of neonatal with bac-terial infectious pneumonia was 0.929,which was larger than the AUC of serum NOX-4 and STAT3 alone(Z=2.083,3.846;P<0.05).Conclusion High expression of serum NOX-4 and STAT3 can increase the risk of bacterial infection in neonates with pneumonia.Detection of serum NOX-4 and STAT3 levels has a positive significance in the early diagnosis and treatment of neonatal pneumonia.关键词
烟酰胺腺嘌呤二核苷酸磷酸氧化酶4/信号转导和转录激活子3/新生儿肺炎/早期诊断/治疗Key words
nicotinamide adenine dinucleotide phosphate oxidase 4/signal transducer and activator of transcription 3/neonatal pneumonia/early diagnosis/treatment分类
临床医学引用本文复制引用
李华兵,余少华,李林..血清NOX-4、STAT3在肺炎新生儿发生细菌性感染的早期诊断及治疗评价中的作用[J].检验医学与临床,2025,22(8):1133-1137,5.
