检验医学与临床2025，Vol.22Issue(8)：1148-1152,5.DOI:10.3969/j.issn.1672-9455.2025.08.027
CXCL9、CXCL10、CXCL11/CXCR3轴在调控肿瘤及治疗方面的作用
The role of CXCL9,CXCL10,CXCL11/CXCR3 axes in tumor regulation and therapy
摘要
Abstract
Chemokines are small molecule secreted proteins produced by tumor cells and stromal cells,which can be divided into CXC,CC,CX3C and C,and the CXC is the most studied subtype.CXC chemokine ligands(CXCL)9,10 and 11 play an important role in the immune system by interacting with their homolo-gous CXC chemokine receptor 3(CXCR3),and are closely related to the occurrence and development of malig-nant tumors.In this review,the research progress of CXCL9,CXCL10,CXCL11/CXCR3 axis was reviewed,in-cluding their direct regulation of tumor cell proliferation and metastasis,indirect regulation of vascular endo-thelial cells,mediating cell targeted movement in tumor microenvironment,and its relationship with immuno-therapy.In addition,the potential of regulating chemokines in combination with other therapies to treat cancer is discussed.关键词
CXC趋化因子配体10/CXC趋化因子配体9/CXC趋化因子配体11/CXC趋化因子受体3/肿瘤微环境/治疗Key words
CXC chemokine ligand 10/CXC chemokine ligand 9/CXC chemokine ligand 11/CXC chemokine receptor 3/tumor microenvironment/treatment分类
医药卫生引用本文复制引用
赵永馨,周陈静雯,刘畅,卫彬,高勇..CXCL9、CXCL10、CXCL11/CXCR3轴在调控肿瘤及治疗方面的作用[J].检验医学与临床,2025,22(8):1148-1152,5.基金项目
国家自然科学基金青年科学基金项目(82103318) （82103318）
江苏省自然科学基金面上项目(BK20211112). （BK20211112）
