兰州大学学报（医学版）2025，Vol.51Issue(3)：1-7,7.DOI:10.13885/j.issn.1000-2812.2025.03.001
乳腺癌发展中脂质代谢重编程的调控机制研究进展
Advances in the study of the role of lipid metabolic reprogr-amming in regulating breast cancer development
摘要
Abstract
Breast cancer is the malignant tumor with the highest morbidity and mortality rate among women,and reprogramming lipid metabolism would effectively regulate tumor metabolic programs to meet the energy demands of tumor cells during proliferation,invasion and metastasis.Starting from the driving role of lipid metabolism in tumor progression,this paper has detailed the specific mechanisms by which fatty acid and cho-lesterol synthesis,uptake and oxidation promote breast cancer progression,as well as the potential mecha-nisms by which lipid metabolic reprogramming of stromal cells in the tumor microenvironment interacts with tumor cells to induce aberrant behaviors in tumor cells,and explored possible future novel antitumor therapeu-tic strategies targeting the lipid metabolic signaling pathway,either alone or in combination.It also explored new strategies for future antitumor therapy that may target lipid metabolism signaling pathways,either alone or in combination.关键词
脂质代谢/乳腺癌/肿瘤微环境/靶向治疗Key words
lipid metabolism/breast cancer/tumor microenvironment/targeted therapy分类
临床医学引用本文复制引用
朱凯丽,曹梦悦,党永霞,令晓玲..乳腺癌发展中脂质代谢重编程的调控机制研究进展[J].兰州大学学报（医学版）,2025,51(3):1-7,7.基金项目
甘肃省科技计划重点研发项目(23YFFA0035) （23YFFA0035）
甘肃省自然科学基金项目(21JR11R076) （21JR11R076）
兰州市科技发展指导性计划项目(2019-ZD-42) （2019-ZD-42）
甘肃省兰州市城关区科学技术局基金项目(2021SHFZ0006) （2021SHFZ0006）
"新锐肿瘤支持治疗课题研究"公益项目(cphcf-2022-013) （cphcf-2022-013）
