兰州大学学报（医学版）2025，Vol.51Issue(3)：8-13,6.DOI:10.13885/j.issn.1000-2812.2025.03.002
SOX10在三阴性乳腺癌中的表达及其与肿瘤免疫浸润特征的相关性
Association between the expression of SOX10 in triple negative breast cancer and its tumor infiltrated immune cell
摘要
Abstract
Objective To elucidate the expression and significance of SOX10 in triple-negative breast cancer(TNBC),this study investigated the relationship between SOX10 expression and the clinicopathological fea-tures of TNBC as well as the infiltration of CD8+T cells in the tumor stroma.Method We collected 85 breast cancer surgical specimens diagnosed as non-specific invasive ductal carcinoma in The First People's Hospital of Lanzhou City from January 1,2018 to May 30,2024,postoperatively,including 45 cases of TNBC.Using the immunohistochemical staining techniques,we examined the expression of SOX10,cytokeratin5/6,epidermal growth factor receptor in the cancerous tissues,and the expression level of CD8 in the tumor stro-ma.Furthermore,by utilizing the TIMER database,we analyzed the relationship between SOX10 gene expres-sion and the purity of basal-like breast cancer,as well as the infiltration of CD8+T cells in the tumor stroma.Result SOX10 was exclusively expressed in triple-negative breast cancer(TNBC)tissues,with no expression observed in all non-triple-negative invasive ductal carcinoma tissues.The expression rate of SOX10 in TNBC was 60%(27/45).The expression of SOX10 in TNBC was correlated with the ages of patients(P<0.05),but not related to the pathological grade,TNM stage,the maximum diameter of the tumor,or the status of lymph node metastasis.In SOX10-expressing TNBC,the proportion of basal-like breast cancer was as high as 81.48%(22/27).Compared with TNBC that did not express SOX10,the number of CD8+T cell infiltration in the tumor stroma of SOX10-expressing TNBC was significantly reduced.Conclusion SOX10 is a sensitive marker for differential diagnosis of TNBC,and tends to express in the cancer tissues of younger patients.In addition,the tumor tissues of SOX10-expressing TNBC are likely to mainly originate from the basal cells of the breast,and the expression of SOX10 may inhibit the infiltration of CD8+T cells in the TNBC tumor stroma.关键词
SOX10/三阴性乳腺癌/临床病理特征/基底样乳腺癌/CD8+T细胞浸润Key words
SOX10/triple negative breast cancer/clinical pathological features/basal-like breast cancer/CD8+T cell infiltration分类
临床医学引用本文复制引用
陈宝强,李东海,郝婷,闫秀英,徐海成,王芙蓉..SOX10在三阴性乳腺癌中的表达及其与肿瘤免疫浸润特征的相关性[J].兰州大学学报（医学版）,2025,51(3):8-13,6.基金项目
甘肃省自然科学基金资助项目(22JR5RA1063) （22JR5RA1063）
