兰州大学学报（医学版）2025，Vol.51Issue(3)：81-89,94,10.DOI:10.13885/j.issn.1000-2812.2025.03.011
双糖链蛋白聚糖调控恶性肿瘤的分子机制研究进展
Research advances on the molecular mechanisms of biglycan in regulating malignant tumors
摘要
Abstract
The extracellular matrix(ECM)plays a pivotal role in maintaining tissue architecture and medi-at-ing extracellular signaling.Biglycan(BGN),a small leucine-rich proteoglycan,serves as a core component of the ECM.It participates in physiological regulation by orchestrating collagen fiber scaffold assembly and me-diating intercellular signaling pathways.BGN exhibits overexpression features in various malignant tumors,with its expression levels significantly correlated with tumor aggressiveness and poor clinical prog-nosis.In metastatic malignancies,aberrant BGN expression facilitates tumor cell migration and invasion,high-lighting its role as a critical regulatory molecule throughout tumorigenesis.This review elucidated BGN-regu-lated sig-naling pathways and functional heterogeneity across different cancer types,and systematically sum-marized the as-sociation between BGN overexpression and invasive tumor growth coupled with unfavorable clinical out-comes,thereby providing insights for developing BGN-targeted anticancer therapeutic strategies.关键词
双糖链蛋白聚糖/细胞外基质/侵袭/转移/恶性肿瘤Key words
biglycan/extracellular matrix/invasive/metastasis/malignant tumour分类
临床医学引用本文复制引用
黄翌楚,闵光涛,妥薇薇,张嘉诺,李倩,边康睿,姜雷,李玉民..双糖链蛋白聚糖调控恶性肿瘤的分子机制研究进展[J].兰州大学学报（医学版）,2025,51(3):81-89,94,10.基金项目
甘肃省重大科技专项资助项目(22ZD6FA050,22JR9KA002) （22ZD6FA050,22JR9KA002）
甘肃省自然科学基金资助项目(17JR5RA224,23JRRA1001) （17JR5RA224,23JRRA1001）
兰州大学医学科研创新能力提升资助项目(lzuyxcx-2022-154,lzuyxcx-2022-141,lzuyxcx-2022-175) （lzuyxcx-2022-154,lzuyxcx-2022-141,lzuyxcx-2022-175）
