临床口腔医学杂志2025，Vol.41Issue(4)：201-204,4.DOI:10.3969/j.issn.1003-1634.2025.04.003
间歇性禁食通过NF-κB通路减轻牙周炎小鼠牙槽骨吸收
Intermittent fasting reduces alveolar bone resorption in periodontitis mice via NF-κB pathway
摘要
Abstract
Objective:To investigate whether intermittent fasting can alleviate alveolar bone resorption in periodonti-tis mice and explore possible molecular mechanisms.Methods:Periodontitis mice were randomly divided into two groups,with the control group mice being able to eat freely,the experimental group received intermittent fasting.After 8 weeks,maxil-la was obtained for Micro-CT and H&E staining,and the mandible was obtained for Western Blot and qRT-PCR test.Results:Micro-CT and H&E staining showed the alveolar bone resorption area of mice in intermittent fasting group was significantly reduced.Western Blot showed a significant decrease in p-P65/P65 protein expression in periodontal tissue in the intermittent fasting group.qRT-PCR showed that the gene expression of Il-1β,Tnf-α,Mmp-9,C-fos,and Nfatc1 in the intermittent fasting group was significantly reduced..Conclusion:Intermittent fasting can alleviate alveolar bone resorption in periodontitis mice,and its mechanism may be through the inhibition of NF-κB pathway.关键词
间歇性禁食/牙周炎/核因子κBKey words
Intermittent fasting/Periodontitis/Nuclear factor-kappaB(NF-kappaB)分类
口腔医学引用本文复制引用
任杰,杨凯..间歇性禁食通过NF-κB通路减轻牙周炎小鼠牙槽骨吸收[J].临床口腔医学杂志,2025,41(4):201-204,4.基金项目
重庆市自然科学基金项目(CSTB2023NSCQ-BHX0217) （CSTB2023NSCQ-BHX0217）
重医一院院内培育科研基金(PYJJ2022-08) （PYJJ2022-08）
