临床小儿外科杂志2025，Vol.24Issue(3)：226-230,5.DOI:10.3760/cma.j.cn101785-202402003-005
劈离式肝移植治疗家族性高胆固醇血症
Clinical insights on split liver transplantation for familial hypercholesterolemia
童翾 1汤睿 1李龙 2卢倩1
作者信息
- 1. 清华大学附属北京清华长庚医院 清华大学临床医学院肝移植科,北京 102218
- 2. 清华大学附属北京清华长庚医院 清华大学临床医学院儿外科,北京 102218
- 折叠
摘要
Abstract
Objective To explore the efficacy and prognosis of split liver transplantation(SLT)for fa-milial hypercholesterolemia(FH).Methods A single-center retrospective study was conducted for 5 FH chil-dren undergoing SLT from September 2020 to March 2022.There were 4 girls and 1 boy with a median age of 11(5-15)year.Clinical and follow-up data were collected,including low-density lipoprotein cholesterol(LDL-C)and total cholesterol(TC)at pre-operation,Month 1 post-operation and the last follow-up,as well as the occur-rence and survival of transplant-related postoperative complications.Results All of them were followed up com-pletely with a median follow-up period of 31(19-35)month.LDL-C(16.31±2.24)mmol/L at pre-operation declined to(2.24±0.63)mmol/L at Month 1 post-operation.There was statistical significance(P＜0.001).LDL-C was(2.07±0.84)mmol/L at the last follow-up showed no significant difference with that at Month 1 post-operation(P=0.893).Preoperative TC(18.13±2.27)mmol/L dropped to(3.79±0.35)mmol/L at Month 1 post-operation and the difference was statistically significant(P＜0.001).No significant difference ex-isted in TC(3.62±0.92)mmol/L at the last postoperative follow-up as compared with Month 1 post-operation(P=0.749).Postoperative lipid-lowering therapy was not required and there were no cardiovascular complica-tions.Conclusions SLT may effectively treat familial hypercholesterolemia.关键词
肝移植/高胆固醇血症/外科手术/儿童Key words
Liver Transplantation/Hypercholesterolemia/Surgical Procedures,Operative/Child引用本文复制引用
童翾,汤睿,李龙,卢倩..劈离式肝移植治疗家族性高胆固醇血症[J].临床小儿外科杂志,2025,24(3):226-230,5.
