临床小儿外科杂志2025，Vol.24Issue(3)：288-291,4.DOI:10.3760/cma.j.cn101785-202411008-016
HMGB1:急性肺损伤"肺-脑轴"炎症关联的关键介质与治疗新靶标
HMGB1:a critical mediator and novel therapeutic target in the"lung-brain axis"inflammatory con-nection of acute lung injury
摘要
Abstract
Acute lung injury(ALI)and its more severe form,acute respiratory distress syndrome(ARDS),are lung diseases with high mortality rates.They are often complicated by brain injury,significantly affecting treatment and prognosis.Inflammatory plays a pivotal role in the"lung-brain axis"of ALI.As a critical pro-inflammatory factor,extracellular high mobility group box 1 protein(HMGB1)is widely implicated in the pathogenesis of both pulmonary and cerebral injuries.Inhibiting HMGB1 release is expected to disrupt inflam-matory crosstalk between the lung and brain,offering novel insights and potential therapeutic targets for mitiga-ting combined lung and brain damage.关键词
HMGB1/急性肺损伤/肺-脑轴/脑损伤Key words
HMGB1/Acute Lung Injury/Lung-Brain Axis/Brain Injury引用本文复制引用
朱丽玲,肖婷,屈双权..HMGB1:急性肺损伤"肺-脑轴"炎症关联的关键介质与治疗新靶标[J].临床小儿外科杂志,2025,24(3):288-291,4.基金项目
湖南省自然科学基金面上项目(2024JJ5220) General Program of Hunan Provincial Natural Science Foundation(2024JJ5220) （2024JJ5220）
