南京师大学报（自然科学版）2025，Vol.48Issue(2)：47-61,15.DOI:10.3969/j.issn.1001-4616.2025.02.006
中药联合化疗治疗中晚期非小细胞肺癌的系统评价和中药有效成分筛选及其机制研究
Systematic Evaluation of Traditional Chinese Medicine Combined with Chemotherapy in the Treatment of Advanced Non-small Cell Lung Cancer and Screening of Effective Components of Traditional Chinese Medicine and Its Mechanism
摘要
Abstract
Traditional Chinese medicine plays an important role in both directly inhibiting tumor growth and assisting western medicine in the treatment of tumors.In this paper,the study searched CNKI,Wanfang,VIP,Pubmed,Web of Science and other databases to include randomized controlled trials of traditional Chinese medicine decoction combined with chemotherapy in the treatment of NSCLC.The efficacy,safety and mechanism of traditional Chinese medicine combined with chemotherapy in the treatment of non-small cell lung cancer(NSCLC)were systematically evaluated by Meta,medication rules,network pharmacology and cell experiments.The efficacy,safety and mechanism of traditional Chinese medicine combined with chemotherapy in the treatment of non-small cell lung cancer were systematically evaluated by Meta,medication rules,network pharmacology and other analytical methods.Finally,56 articles were included for statistical analysis,a total of 4992 patients,57 prescriptions,and 172 Chinese medicines.The results showed that the total effective rate,liver function injury,gastrointestinal reaction and 1-year survival rate of the combined treatment group were better than those of the chemotherapy group.There were 7 flavors with medication frequency>20,the flavor of the medicine was mainly sweet and bitter,the medicinal properties were mainly cold and warm,mainly classified as lung meridian and liver meridian,5 high-frequency drug clusters were obtained,4 drug combinations with the highest confidence obtained by association rule analysis,that were Trichosanthis Radix-Ophiopogon japonicus,Polygonatum odoratum-Ophiopogon japonicus,Glehniae Radix-Polygonatum odoratum-Ophiopogon japonicus,Atractylodes-Astragali Radix-Codonopsis Radix.A total of 126 potential targets of core Chinese medicine components and NSCLC intersection targets were collected.Three core targets were obtained by PPI analysis:AKT1,EGFR and SRC.KEGG analysis showed that the key pathway was PI3K-Akt signaling pathway.Three key components were screened,that were luteolin,quercetin and kaempferol,the results of molecular docking showed that the key components and core targets could be stably combined.The results of cell experiments showed that luteolin could effectively inhibit the proliferation,viability and migration of A549 cells,induce apoptosis and change their morphology.The results of this paper showed that traditional Chinese medicine combined with chemotherapy in the treatment of NSCLC could improve its clinical efficacy and reduce the toxic and side effects of chemotherapy.Astragali Radix,Ophiopogon japonicus,Codonopsis Radix,Glehniae Radix and other core components of traditional Chinese medicine can treat NSCLC through multi-target and multi-channel synergy,luteolin can inhibit the proliferation,viability and migration of A549 cells,and induce their apoptosis.关键词
非小细胞肺癌/中药/Meta分析/用药规律/网络药理学/分子对接/生物学验证Key words
non-small cell lung cancer/Chinese medicine/Meta-analysis/compatibility rules/network pharmacology/molecular docking/biological validation分类
化学引用本文复制引用
唐乾,先正平,唐钰,曹洪玉,王立皓,佟昊聪,杜亚男,郑学仿..中药联合化疗治疗中晚期非小细胞肺癌的系统评价和中药有效成分筛选及其机制研究[J].南京师大学报（自然科学版）,2025,48(2):47-61,15.基金项目
国家自然科学基金项目(21571025、21601024、21601025、21601023)、大连大学学科建设专项-学科交叉项目(DLUXK-2023-YB-007)、大连大学学科平台项目(202101ZD01). （21571025、21601024、21601025、21601023）
