南通大学学报（自然科学版）2025，Vol.24Issue(1)：85-94,10.DOI:10.12194/j.ntu.20231113001
基于柱芳烃的主动靶向药物递送体系的设计策略
The design strategy for pillararene based active targeted drug delivery systems
摘要
Abstract
Pillararenes feature columnar structures with electron-rich cavities,enabling distinctive host-guest comple-xation properties,while their structural adaptability supports diverse applications.In the context of improving cancer treatment outcomes,active targeted drug delivery systems(DDSs)are recognized as vital.The inherent structural flexi-bility and host-guest interactions of pillararenes facilitate the integration of tumor-targeting groups into pillararene-based DDSs,allowing precise drug delivery to tumor sites.This review delineates two design strategies for such sys-tems.One approach employs host-guest complexation to incorporate targeting groups through noncovalent bonds,avoiding the need for intricate organic synthesis.Alternatively,pillararenes modified with targeting groups are synthe-sized directly,yielding DDSs with stable targeting capabilities and consistent reproducibility,albeit at the expense of increased time and cost due to complex organic synthesis processes.关键词
柱芳烃/药物递送/癌症治疗Key words
pillararenes/drug delivery/cancer therapy分类
化学工程引用本文复制引用
全慧,卢冰..基于柱芳烃的主动靶向药物递送体系的设计策略[J].南通大学学报（自然科学版）,2025,24(1):85-94,10.基金项目
国家自然科学基金青年科学基金项目(32301184) （32301184）
