日用化学工业（中英文）2025，Vol.55Issue(4)：430-436,7.DOI:10.3969/j.issn.2097-2806.2025.04.004
防晒类化妆品中二氧化钛纳米颗粒的筛查方法研究
Research on screening methods for TiO2 nanoparticles in sunscreen cosmetics
摘要
Abstract
A method was developed for the determination of particle size and distribution of titanium dioxide nanoparticles in sunscreen using single particle-inductively coupled plasma-mass spectrometry(spICP-MS).The titanium dioxide nanoparticles were characterized by high resolution transmission electron microscopy(HRTEM)and energy dispersive spectroscopy(EDS).0.1%Triton X-100 was employed as an extractant for ultrasound-assisted extraction of titanium dioxide nanoparticles in cosmetics.The data were acquired in pulse signal mode,and the particle size and distribution were determined through calculation.The experimental results demonstrate that the lower limit of particle size detection is influenced not only by the background signal of the isotope to be detected but also by the cosmetic matrix.Different background thresholds significantly affect both the lower limit of particle size detection and the number of identified particles,thereby directly impacting compliance and safety considerations for cosmetics.This method enables rapid screening of titanium dioxide nanoparticles in sunscreen cosmetics while simultaneously determining and characterizing their particle size and distribution,providing a framework for discussing compliance and safety investigations regarding nanoparticle-containing cosmetics.关键词
单颗粒电感耦合等离子体质谱法/纳米二氧化钛/背景阈值/防晒类化妆品Key words
single particle inductively coupled plasma mass spectrometry(spICP-MS)/titanium dioxide nanoparticle(TiO2-NP)/threshold criterion/sunscreen分类
化学化工引用本文复制引用
李硕,代静,李庆武,李莉..防晒类化妆品中二氧化钛纳米颗粒的筛查方法研究[J].日用化学工业（中英文）,2025,55(4):430-436,7.基金项目
中国计量科学研究院基本科研业务费项目(AKYZZ2443) （AKYZZ2443）
中国食品药品检定研究院中青年发展研究基金项目(2018C02) （2018C02）
