日用化学工业（中英文）2025，Vol.55Issue(4)：508-515,8.DOI:10.3969/j.issn.2097-2806.2025.04.013
共聚焦拉曼光谱在皮肤屏障功能评估和经皮吸收研究中的应用
Application of confocal Raman spectroscopy in the evaluation of skin barrier function and permeability
摘要
Abstract
Confocal Raman spectroscopy(CRS)is a new analytical technology in the field of percutaneous absorption,which enables physiology analysis to obtain information on the molecular composition and structure of the skin.Due to the advantages of high spatial resolution,non-invasive and non-pretreatment of sample compared to conventional methods,CRS possesses great potential to become a standardized laboratory analytical technique.Currently,the development and application of CRS is still in a stage of improvement.This review focuses on elucidating the principles and the advantages of this technology,and summarizes the application of CRS technique in skin research,including the skin barrier function assessment and permeation research.Furthermore,the limitations of CRS,such as the attenuation of signal and the interference of skin autofluorescence are analyzed,and the challenges and opportunities in CRS technology are also discussed.关键词
经皮吸收/共聚焦拉曼光谱/皮肤屏障/局限性Key words
percutaneous absorption/confocal Raman spectroscopy/skin barrier/limitation分类
化学工程引用本文复制引用
杨武成,谢宇,魏剑,范瑞芳,谭建华,席绍峰..共聚焦拉曼光谱在皮肤屏障功能评估和经皮吸收研究中的应用[J].日用化学工业（中英文）,2025,55(4):508-515,8.基金项目
国家自然科学基金(42377366) （42377366）
广州市科技项目"广州市NQI-质量安全科技协同创新中心"(No.2023B04J0407) （No.2023B04J0407）
广东省药监局科技创新项目(No.2021TDB38) （No.2021TDB38）
