肿瘤预防与治疗2025，Vol.38Issue(4)：306-311,6.DOI:10.3969/j.issn.1674-0904.2025.04.008
术前临床I期(cT1N0M0)卵巢透明细胞癌淋巴结切除数目对分期及预后的影响:一项基于SEER数据库的研究
Impact of Lymph Node Count on Staging and Prognosis of Preoperative Clinical Stage I(cT1N0M0)Ovarian Clear Cell Carcinoma:A Study Based on SEER Database
摘要
Abstract
Objective:Systematic lymphadenectomy has long been an essential component of comprehensive staging sur-gery for ovarian cancer.However,its role in preoperatively diagnosed FIGO stage Ⅰ ovarian clear cell carcinoma(OCCC)re-mains controversial,as overly extensive lymph node dissection may lead to various surgical complications.The aim of this study was to explore the effect of lymph node count(LNC)on the staging and prognosis in clinical stage Ⅰ OCCC.Methods:Clinical and prognostic data of patients surgically diagnosed with pT1N0-1M0 OCCC between 2010 and 2017 were collected from the SEER database.The optimal lymph node yield was determined using X-tile software,with patients subsequently stratified into Group A(≥32 lymph nodes removed)and Group B(<32 lymph nodes removed).The comparison of lymph node positivity rates and other parameters was performed using the chi-square test,while survival analysis was conducted with Kaplan-Meier curves and log-rank tests.Results:A total of 842 patients diagnosed with pT1N0-1M0-stage OCCC were in-cluded.The median number of dissected lymph nodes was 16(IQR 8,23),with lymph node metastasis identified in 51 ca-ses(6.1％).The median number of metastatic lymph nodes was 2(IQR 1,3)in node-positive patients.The 3-year canc-er-specific survival rates were 91.5％and 88.8％in groups A and B,respectively,while the 5-year cancer-specific survival rates were 86.3％and 81.8％,with a statistically significant difference(χ2=5.902,P=0.021).Additionally,Group A showed a slightly higher lymph node positivity rate(6.7％)compared to Group B(6.0％),though this difference was not statistically significant(χ2<0.001,P=0.978).Conclusion:Based on our findings,resection of≥32 lymph nodes should be adopted as the standard surgical approach for accurate nodal staging and optimal outcomes in clinical stage Ⅰ OCCC.关键词
临床I期卵巢透明细胞癌/淋巴结清扫术/肿瘤特异性生存期Key words
Clinical stage Ⅰ ovarian clear cell carcinoma/Lymphadenectomy/Cancer-specific survival分类
临床医学引用本文复制引用
刘晓时,王登凤,张国楠..术前临床I期(cT1N0M0)卵巢透明细胞癌淋巴结切除数目对分期及预后的影响:一项基于SEER数据库的研究[J].肿瘤预防与治疗,2025,38(4):306-311,6.基金项目
四川省肿瘤医院优秀青年基金(编号:YB2024 013) This study was supported by grants from Sichuan Cancer Hospital(No.YB20240113). （编号:YB2024 013）
