肿瘤预防与治疗2025，Vol.38Issue(4)：334-340,7.DOI:10.3969/j.issn.1674-0904.2025.04.012
子宫颈神经内分泌癌发生发展机制及临床治疗的研究进展
Research Progress on the Pathogenesis and Clinical Treatment of Cervical Neuroendocrine Carcinoma
摘要
Abstract
Neuroendocrine carcinoma of the cervix(NECC)is a rare and highly aggressive malignancy demonstrating sig-nificantly higher rates of lymphovascular invasion,metastasis,and recurrence compared with cervical squamous cell carcino-ma and adenocarcinoma.NECC is strongly associated with high-risk human papillomavirus(HPV)infection,with HPV-18 being the predominant subtype.Viral infections may induce genetic mutations and activate signaling pathways,thereby pro-moting tumorigenesis and driving tumor progression.Given its histopathological resemblance to small cell lung cancer(SCLC),the clinical management of NECC integrates the staging system of cervical carcinoma with therapeutic regimens a-dapted from SCLC protocols,establishing a multimodal treatment paradigm centered on comprehensive therapy.Precision medicine represents the definitive evolution in NECC management,where immunotherapy and targeted therapies have e-merged as groundbreaking modalities and constitute pivotal frontiers in therapeutic innovation.Going forward,we aim to conduct in-depth investigations into the molecular pathogenesis of NECC,with a dedicated focus on discovering actionable therapeutic targets,thereby pioneering transformative thera-peutic frontiers for NECC.关键词
宫颈神经内分泌癌/预后/分子机制/靶向治疗/免疫治疗Key words
Neuroendocrine carcinoma of the cervix/Prognosis/Molecular pathogenesis/Targeted therapy/Immunother-apy分类
医药卫生引用本文复制引用
江晓霞,郝宇杰,李政..子宫颈神经内分泌癌发生发展机制及临床治疗的研究进展[J].肿瘤预防与治疗,2025,38(4):334-340,7.基金项目
This study was supported by grants from Science and Technology Department of Yunnan Province(No.202401AY070001-015). 云南省科技厅科技计划项目(编号:202401 AY070001-015) （No.202401AY070001-015）
