时珍国医国药2025，Vol.36Issue(6)：1045-1049,5.DOI:10.70976/j.1008-0805.SZGYGY-2025-0608
通络三生饮酊剂缓解癌性疼痛的作用及对IL-1β、TNF-α和PGE2的影响
On the effect of Tongluo Sanshengyin Tincture(通络三生饮酊剂)on alleviating cancer pain and its impact on IL-1β,TNF-α and PGE2
摘要
Abstract
Objective To investigate the mechanism of Tongluo Sanshengyin Tincture(通络三生饮酊剂,TST)in treating the cancer pain by establishing a mouse model of cancer pain.Methods S180 cells were inoculated into the muscle around the right sciatic nerve of KM mice to establish a cancer pain model via tumor compression of the sciatic nerves.The mice were randomly divided into the model group,high-dose TST group,low-dose TST group,and control group(10 mice per group),with an additional10 healthy KM mice serving as the blank group.All groups contained half male and half female mice.After successful modeling,the drug was administered for 12 consecutive days.Before and after treatment,the thermal pain threshold and mechanical pain threshold of mice were detected by hot plate instrument and Von Frey filaments,and the contents of IL-1β,TNF-α and PGE2 in serum and tumor were detected by ELISA.Results Compared with the blank group,the thermal pain threshold and mechanical pain threshold of mice in the model group,high-dose TST group,low-dose TST group,and control group were all decreased on the 8th day after modeling(P<0.01),without differences between groups(P>0.05).After treatment,both high-dose and low-dose TST groups exhibited increased thresholds of thermal pain and mechanical pain(P<0.01,P<0.05)and reduced contents of IL-1β,TNF-α,and PGE2 in serum(P<0.01,P<0.05),compared with the model group.Conclusion TST can alleviate cancer pain in mice,and its mechanism may be related to in-hibiting peripheral inflammatory factor levels.关键词
通络三生饮酊剂/癌性疼痛/炎症因子/白介素-1β/肿瘤坏死因子-α/前列腺素2Key words
Tongluo Sanshengyin Tincture(通络三生饮酊剂)/Cancer pain/Inflammatory factors/IL-1β/TNF-α/PGE2分类
医药卫生引用本文复制引用
孙民朋,施艾每,徐方园,贾金虎,郭伟,孙宏新..通络三生饮酊剂缓解癌性疼痛的作用及对IL-1β、TNF-α和PGE2的影响[J].时珍国医国药,2025,36(6):1045-1049,5.基金项目
河南省中医药重点学科建设项目(豫卫中医药科教[2014]1号) （豫卫中医药科教[2014]1号）
张仲景传承与创新专项(GZY-KJS-20220382) （GZY-KJS-20220382）
河南省中西医学免疫工程研究中心(豫发改高技[2020]701号) （豫发改高技[2020]701号）
