数字中医药（英文）2025，Vol.8Issue(1)：49-58,10.DOI:10.1016/j.dcmed.2025.03.005
糖脂代谢紊乱的中医表型组学研究概况
Traditional Chinese medicine phenomics research on glycolipid metabolism disorder:a review
摘要
Abstract
Traditional Chinese medicine(TCM)has demonstrated unique advantages in the prevention and treatment of chronic diseases such as glycolipid metabolism disorder.However,its widespread application has been hindered by the unclear biological essence of TCM syn-dromes and therapeutic mechanisms.As an emerging interdisciplinary field,phenomics inte-grates multi-dimensional data including genome,transcriptome,proteome,metabolome,and microbiome.When combined with TCM's holistic philosophy,it forms TCM phenomics,providing novel approaches to reveal the biological connotation of TCM syndromes and the mechanisms of herbal medicine.Taking glycolipid metabolism disorder as an example,this paper explores the application of TCM phenomics in glycolipid metabolism disorder.By ana-lyzing molecular characteristics of related syndromes,TCM phenomics identifies differential-ly expressed genes,metabolites,and gut microbiota biomarkers to elucidate the dynamic evo-lution patterns of syndromes.Simultaneously,it deciphers the multi-target regulatory net-works of herbal formulas,demonstrating their therapeutic effects through mechanisms in-cluding modulation of insulin signaling pathways,improvement of gut microbiota imbalance,and suppression of inflammatory responses.Current challenges include the subjective na-ture of syndrome diagnosis,insufficient standardization of animal models,and lack of inte-grated multi-omics analysis.Future research should employ machine learning,multimodal data integration,and cross-omics longitudinal studies to establish quantitative diagnostic sys-tems for syndromes,promote the integration of precision medicine in TCM and western medicine,and accelerate the modernization of TCM.关键词
中医药/表型组学/多组学/糖脂代谢紊乱/证候Key words
Traditional Chinese medicine(TCM)/Phenomics/Multi-omics/Glycolipid metabolism disorder/Syndrome引用本文复制引用
方心怡,缪林轩,张艳娇,张宇昕,苗润宇,关惠芳,田佳星..糖脂代谢紊乱的中医表型组学研究概况[J].数字中医药（英文）,2025,8(1):49-58,10.基金项目
National Natural Science Foundation of China(82474323),High Level Chinese Medical Hospital Promo-tion Project(HLCMHPP20230CZ40907),and China Academy of Chinese Medical Sciences Outstanding Young Scientific and Technological Talents Program(ZZ13-YQ-026). （82474323）
