外科理论与实践2025，Vol.30Issue(1)：27-33,7.DOI:10.16139/j.1007-9610.2025.01.06
第5版WHO内分泌和神经内分泌肿瘤分类解读:甲状腺滤泡细胞起源肿瘤的更新及进展
Interpretation of the 5th edition of WHO classification of endocrine and neuroendocrine tumors:update and progress on follicular cell-derived thyroid tumors
鲁姗姗 1纪元1
作者信息
- 1. 复旦大学附属中山医院病理科,上海 200032
- 折叠
摘要
Abstract
The 2022 WHO classification of endocrine and neuroendocrine tumors(5th edition)categorizes thyroid follicular cell-derived tumors into benign,low-risk,and malignant types.Benign tumors now include thyroid follicular nodular lesions.A newly added category previously termed"borderline tumors"have been revised to low-risk follicular cell-derived tumors,which encompass non-invasive follicular thyroid neoplasm with papillary-like nuclear features,thyroid tumors of uncertain malignant potential,and hyalinizing trabecular tumors.The new WHO classification stratifies malignant follicular cell-derived tumors based on molecular characteristics and invasiveness:papillary thyroid carcinoma(PTC)with various histological subtypes represents BRAF-like malignancies;invasive encapsulated follicular variant PTC and follicular thyroid carcinoma represent RAS-like malignancies.Oncocytic carcinoma is now recognized as a distinct entity,specifically referring to tumors composed of≥75%oncocytic follicular cells lacking PTC nuclear features and high-grade characteristics(necrosis and mitotic figures≥3/2 mm²).A new category termed"high-grade follicular cell-derived thyroid carcinoma"has been added,encompassing traditional poorly differentiated thyroid carcinoma and differentiated high-grade thyroid carcinoma.Anaplastic thyroid carcinoma(ATC)remains the most undifferentiated type,with thyroid squamous cell carcinoma now classified as a subtype of ATC.The term"papillary thyroid microcarcinoma"is no longer recommended as a distinct subtype.Cribriform-morular thyroid carcinoma is no longer classified as a subtype of PTC,but is instead categorized as a tumor of uncertain histogenesis.关键词
甲状腺肿瘤/甲状腺滤泡细胞/内分泌和神经内分泌肿瘤/肿瘤分类/病理诊断Key words
Thyroid tumor/Thyroid follicular cell/Endocrine and neuroendocrine tumor/Tumor classification/Pathological diagnosis分类
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鲁姗姗,纪元..第5版WHO内分泌和神经内分泌肿瘤分类解读:甲状腺滤泡细胞起源肿瘤的更新及进展[J].外科理论与实践,2025,30(1):27-33,7.
