外科理论与实践2025，Vol.30Issue(1)：47-53,7.DOI:10.16139/j.1007-9610.2025.01.09
局部进展期直肠癌新辅助治疗后病理完全缓解的预测因素
Predictive factors of pathological complete response after neoadjuvant therapy for locally advanced rectal cancer
摘要
Abstract
Objective To analyze the tumor characteristics associated with achieving pathological complete response(pCR)and tumor prognosis in the patients undergoing laparoscopic rectal cancer surgery after neoadjuvant chemoradiotherapy(nCRT).Methods A retrospective review was conducted on clinical and pathological data of locally advanced rectal cancer(LARC)patients who underwent nCRT at Renji Hospital from January 2017 to January 2024.Factors influencing the achievement of pCR were analyzed,and the patients prognosis of pCR group and non-pCR group was compared.Results Univariate analysis,multivariate Logistic regression analysis,and receiver operating characteristic(ROC)curve analysis showed that tumor length less than 5 cm(cutoff value 5.24 cm)and baseline carcinoembryonic antigen(CEA)less than 5 μg/L(cutoff value 5.33 μg/L)were independent predictors of achieving pCR after nCRT in LARC patients.Prognostic survival analysis showed that the 3-year overall survival(OS)rate for pCR group and non-pCR group were 92.86%and 82.46%,respectively(P=0.193),and the 3-year disease-free survival(DFS)rate were 85.71%and 70.18%,respectively(P=0.141),with no statistically significant differences between the two groups.Conclusions Tumor length and baseline CEA level are independent predictors for achieving pCR after nCRT in LARC patients.Additionally,there were no statistically significant differences in 3-year OS and DFS between pCR group and non-pCR group.关键词
局部进展期直肠癌/新辅助放化疗/病理完全缓解/观察与等待/预后Key words
Locally advanced rectal cancer(LARC)/Neoadjuvant chemoradiotherapy(nCRT)/Pathological complete response(pCR)/Watch and wait(W&W)/Prognosis分类
临床医学引用本文复制引用
李浩,骆洋,王廷峰,林海萍,贡婷月,赵永恒,钟鸣..局部进展期直肠癌新辅助治疗后病理完全缓解的预测因素[J].外科理论与实践,2025,30(1):47-53,7.基金项目
上海申康三年行动计划(SHDC2020CR5006) （SHDC2020CR5006）
