现代技术陶瓷2025，Vol.46Issue(1)：86-97,12.DOI:10.16253/j.cnki.37-1226/tq.2025.01.006
银铜共掺羟基磷灰石仿生涂层的制备与抗菌性能
Preparation and Antibacterial Property of Silver-Copper-Codoped Hydroxyapatite Biomimetic Coating
摘要
Abstract
Aiming at enhancing the antibacterial property of biomedical magnesium alloy with hydroxyapatite coating,silver-copper-codoped hydroxyapatite(AgCuHA)biomimetic coating was prepared on chitosan interlayer.XRD,SEM,EDS,TEM,optical profiler and contact angle tester were applied to analyze the phase,surface morphology,chemical composition,crystal structure,surface roughness and hydrophilicity of the coatings.Spread plate and CCK-8 methods were adopted to test antibacterial property and cell viability of the coatings.The results indicated that AgCuHA coating was constructed by nanodefect-rich nanocones in a bottom-up way,resulting in a kind of biomimetic micro/nano-topography.This hydrophilic biomimetic coating not only showed high antibacterial property,but also inhibited magnesium alloy rapid degradation and demonstrated good cytocompatibility.关键词
银铜共掺羟基磷灰石涂层/仿生拓扑结构/微波水相制备/抗菌性能Key words
silver-copper-codoped hydroxyapatite coating/biomimetic topography/microwave aqueous preparation/antibacterial property分类
通用工业技术引用本文复制引用
王琪,丁秀静,鲍小刚,杨喜月,董博玮,张璐,申偲伯..银铜共掺羟基磷灰石仿生涂层的制备与抗菌性能[J].现代技术陶瓷,2025,46(1):86-97,12.基金项目
河北省三三三人才工程资助项目(C20221031) （C20221031）
国家自然科学基金(51802221). （51802221）
