中国组织工程研究2025，Vol.29Issue(32)：6955-6962,8.DOI:10.12307/2025.965
中药单体治疗类风湿关节炎:T细胞平衡调控
Monomeric traditional Chinese medicine in the treatment of rheumatoid arthritis:regulation of T cell balance
摘要
Abstract
BACKGROUND:Rheumatoid arthritis is a complex autoimmune disease characterized by joint swelling,pain,and progressive damage.The basic pathological changes include synovitis and pannus formation,with T lymphocyte infiltration being the key to its pathogenesis.In recent years,the application of traditional Chinese medicine(TCM)monomers in the treatment of rheumatoid arthritis has attracted increasing attention.They have shown long-lasting effcacy and fewer side effects by regulating the T helper cell 17(Th17)/regulatory T cells(Treg)balance in the treatment of rheumatoid arthritis. OBJECTIVE:To discuss the mechanisms by which TCM monomers regulate the Th17/Treg balance to treat rheumatoid arthritis,based on the latest basic research,providing a solid theoretical basis for future applications of TCM in the treatment of rheumatoid arthritis. METHODS:Using keywords such as"rheumatoid arthritis,Th17/Treg,traditional Chinese medicine,Chinese herbal monomer,"and their Chinese equivalents,literature searches were conducted in PubMed,Web of Science,Embase,Cochrane,VIP,CBM,CNKI,and WanFang databases for relevant studies from their inception to August 2024.Inclusion and exclusion criteria were established,and the articles were screened by reading the titles,abstracts,and full texts.Finally,57 relevant articles were included. RESULTS AND CONCLUSION:(1)TCM monomers have immunoregulatory effects in the treatment of rheumatoid arthritis.They exert therapeutic effects by maintaining the Th17/Treg balance through the regulation of transcription factors,cytokines,signaling pathways,and miRNAs.(2)There may be synergistic effects among some TCM monomers,but the specific mechanisms and enhancement effects in regulating the Th17/Treg balance require further exploration.(3)Regulating the Th17/Treg balance using TCM monomers may become a key clinical therapy for the treatment of rheumatoid arthritis.关键词
Th17/Treg/类风湿关节炎/自身免疫性疾病/中药单体/综述/工程化组织构建Key words
Th17/Treg/rheumatoid arthritis/autoimmune disease/traditional Chinese medicine monomer/review/engineered tissue construction分类
医药卫生引用本文复制引用
祝嘉平,高博,娄纯彪,杨逢永,杨昆..中药单体治疗类风湿关节炎:T细胞平衡调控[J].中国组织工程研究,2025,29(32):6955-6962,8.基金项目
山东省自然科学基金面上项目(ZR2021MH329),项目负责人:杨逢永 （ZR2021MH329）
山东省济南市卫生健康委员会2023年委科技计划项目(2023-1-22),项目负责人:祝嘉平 Natural Science Foundation of Shandong Province(General Program),No.ZR2021MH329(to YFY) （2023-1-22）
2023 Science and Technology Development Program of Jinan Municipal Health Commission,Shandong Province,China,No.2023-1-22(to ZJP) （to ZJP）
