中国组织工程研究2025，Vol.29Issue(32)：7015-7027,13.DOI:10.12307/2025.797
不同来源抗氧化剂与骨关节炎:基于欧洲人群全基因组的关联分析
Antioxidants from different sources and osteoarthritis:a genome-wide association analysis in European populations
摘要
Abstract
BACKGROUND:Currently,numerous observational studies have frequently associated dietary antioxidant intake and circulating antioxidant levels with osteoarthritis.Nevertheless,the underlying causal mechanisms remain unclear.Therefore,this study employs publicly available genome-wide association data to investigate the causal associations between antioxidant intake,circulating levels,and osteoarthritis,offering evidence for the prevention and treatment of osteoarthritis. OBJECTIVE:To assess the potential causal associations between dietary antioxidants(including vitamins A,C,E,and carotenoids)and circulating antioxidants(such as Glutathione S-transferase,glutathione peroxidase,catalase,superoxide dismutase,ascorbic acid,α-tocopherol,γ-tocopherol,albumin,uric acid,bilirubin,zinc,and selenium)with osteoarthritis through Mendelian randomization. METHODS:Data from genome-wide association studies on four dietary antioxidants and twelve circulating antioxidants were employed as exposure variables.The outcome variable was the osteoarthritis consortium dataset,which comprised 77 052 osteoarthritis cases and 378 169 healthy controls.Causal effects were evaluated using the inverse variance-weighted method,MR-Egger regression,and the weighted median approach.Stability and reliability of the findings were assessed through horizontal pleiotropy tests and sensitivity analyses. RESULTS AND CONCLUSION:(1)These results demonstrated that dietary vitamin C intake was inversely associated with knee osteoarthritis risk(OR=0.83,95%CI:0.71-0.96,P=0.015).Conversely,vitamin E intake was positively associated with knee osteoarthritis(OR=1.20,95%CI:1.05-1.34,P=0.004)and both knee and hip osteoarthritis(OR=1.15,95%CI:1.03-1.27,P=0.008).(2)Circulating antioxidant albumin levels were negatively associated with knee(OR=0.94,95%CI:0.91-0.97,P=0.001),hip(OR=0.95,95%CI:0.91-0.99,P=0.03),and knee or hip osteoarthritis(OR=0.95,95%CI:0.92-0.98,P=0.01).Uric acid levels were positively associated with knee osteoarthritis(OR=1.10,95%CI:1.03-1.17,P=0.003).(3)Sensitivity analyses yielded consistent results without evidence of horizontal pleiotropy.(4)European genome-wide data indicated that vitamin C intake was associated with a decreased risk of knee osteoarthritis,and lower serum albumin levels were associated with reduced risks of knee and hip osteoarthritis.In contrast,vitamin E intake and higher serum uric acid were associated with an increased risk of knee osteoarthritis.These findings support public health education and osteoarthritis interventions,indicating that serum albumin could be a potential biomarker for risk assessment.(5)The study underscores the role of certain antioxidants in osteoarthritis prevention and provides evidence to inform nutritional guidelines and public health strategies for the Chinese population.Furthermore,it contributes to biomarker research in arthritis,facilitating the development of early diagnostic tools and risk assessment strategies for the Chinese population.关键词
抗氧化物/膝骨关节炎/髋骨关节炎/孟德尔随机化/逆方差加权法/全基因组关联研究/因果关系/单核苷酸多态性Key words
antioxidants/knee osteoarthritis/hip osteoarthritis/Mendelian randomization/inverse variance weighting/genome-wide association study/causal association/single nucleotide polymorphism分类
医药卫生引用本文复制引用
刘小武,刘金萍,吴婷,贺宪,蔡坚雄..不同来源抗氧化剂与骨关节炎:基于欧洲人群全基因组的关联分析[J].中国组织工程研究,2025,29(32):7015-7027,13.基金项目
广州市科技计划项目(2024A03J0744),项目负责人:蔡坚雄 （2024A03J0744）
广东省中医院优秀论文支持计划,项目负责人:蔡坚雄 Guangzhou Science and Technology Planning Project,No.2024A03J0744(to CJX) （to CJX）
Excellent Paper Support Program of Guangdong Hospital of Traditional Chinese Medicine(to CJX) （to CJX）
