新医学2025，Vol.56Issue(4)：337-344,8.DOI:10.12464/j.issn.0253-9802.2024-0331
抑制CAR-T细胞衰竭的策略研究
Research on strategies to inhibit CAR-T cell exhaustion
摘要
Abstract
Immunotherapy has achieved good efficacy in clinical anti-tumor therapy,especially chimeric antigen receptor T cell(CAR-T cell)therapy,as an emerging tumor immunotherapy,has achieved breakthrough efficacy in the clinical treatment of hematologic malignancies.However,CAR-T cell face the problem of gradual exhaustion during the treatment process,especially in the treatment of solid tumors,which will lead to poor anti-tumor efficacy and possible risks such as recurrence.This paper analyzed the possible mechanism of CAR-T cell exhaustion and describes the relevant research progress in inhibiting CAR-T cell exhaustion,with a view to designing reasonable therapeutic strategies to reduce CAR-T cell exhaustion and improve the efficacy of CAR-T cell.关键词
CAR-T细胞/T细胞衰竭/衰竭机制/调控策略Key words
CAR-T cell/T cell exhaustion/Mechanisms of exhaustion/Governance policies引用本文复制引用
符琼玉,郝新宝,陶石..抑制CAR-T细胞衰竭的策略研究[J].新医学,2025,56(4):337-344,8.基金项目
海南省卫生健康行业科研项目(22A200239) （22A200239）
