新医学2025，Vol.56Issue(4)：386-394,9.DOI:10.12464/j.issn.0253-9802.2024-0310
静脉用硫酸镁改善术后睡眠质量的有效性和安全性:一项系统评价和荟萃分析
Efficacy and safety of intravenous magnesium sulfate in improving postoperative sleep quality:a systematic review and meta-analysis
摘要
Abstract
Objective To systematically evaluate the efficacy and safety of intravenous magnesium sulfate in improving postoperative sleep quality.Methods Clinical randomized controlled trials assessing the role of intravenous magnesium sulfate in improving postoperative sleep quality were searched from PubMed,Web of Science,Embase,Cochrane Library,CNKI,Wanfang,VIP Database,and Grey Literature Database.The retrieval time was from the date of database inception to March 2024.The included literatures were subject to meta-analysis using RevMan 5.4 software after quality evaluation.Results A total of 256 surgical patients from five studies were included.The results of meta-analysis showed that the Visual Analogue Scale(VAS)score(mean difference was-1.49,95%CI ‒1.87～-1.12,P<0.000 01)of sleep quality in the first night in patients receiving perioperative intravenous magnesium sulfate was better than that in the control group,and there were no significant differences in postoperative VAS pain scores under activity status,and the outcomes of nausea and vomiting,shivering and hypotension between two groups(all P>0.05).Conclusion Intravenous magnesium sulfate during perioperative period can improve postoperative sleep quality and bring clinical benefits to patients without severe adverse reactions.关键词
硫酸镁/睡眠质量/静脉用药/系统评价/荟萃分析Key words
Magnesium sulfate/Sleep quality/Intravenous medication/Systematic review/Meta-analysis引用本文复制引用
莫杏樱,张婧婷,张振业,朱茜茜,周少丽..静脉用硫酸镁改善术后睡眠质量的有效性和安全性:一项系统评价和荟萃分析[J].新医学,2025,56(4):386-394,9.基金项目
广东省医学会研究基金(2022375) （2022375）
广东省医院药学研究基金(2020XC06) （2020XC06）
